Lipase-Catalyzed Enantioselective Reaction Based on Remote Recognition of the Stereogenic Carbon Atom Away from the Reaction Site

Abstract

The synthetic method of optically active compound by using lipase-catalysis in organic solvent has been generally accepted recently. Because lipases possess especially broad substrate specificity and are commercially available. However, efficient substrates of lipase-catalyzed asymmetric reactions were limited to be the compounds whose stereogenic carbon atoms were in the neighborhood of the reaction site.
This review describes our investigation on substrates of which stereogenic carbon atoms are remote from the reacting site, leading to lipase-catalyzed asymmetric synthesis of optically active synthetic drugs.