抄録
In recent years there has been a broadly expanding interest in the synthesis of α-heteroatom-substituted phosphonates such as those bearing amino, hydroxy, and fluoro substituents. This interest has resulted from their potential utilities as mimics for α-amino carboxylates and biological phosphates in the biological processes. This review is focussed on the recent development for the efficient synthesis of these α-heteroatom-substituted phosphonates. The examples cited in this review are divided in six distinct types of methods : (a) C-P bond formation, (b) C-C bond formation, (c) heterofunctionalization, (d) conversion of prochiral phosphonates, (e) resolution of α-substituted phosphonates, (f) functional conversion of α-substituted phosphonates.
