Biomimetic Syntheses of Isodityrosine Natural Products, and an Approach to Chemistry and Molecular Recognition of Secoaglucovancomycin and Related Oligopeptides

抄録

The biomimetic oxidation of dihalogenated phenols employing TTN or electrolysis, effected the construction of a diaryl ether linkage, leading to the syntheses of isodityrosine natural products. In particular, the halogen substituents were found to control the oxidation-direction. The vancomycin derivatives were also synthesized, and their interaction to models of bacterial cell wall precursors were observed by NMR techniques, coupled with the theoretical calculations.