New Development of Resolving Agents for Industrial Purposes

Gen HASEGAWA; Tsuyoshi MIURA; Tetsurou WATADANI; Namgi HONG

doi:10.5059/yukigoseikyokaishi.56.773

Gen HASEGAWA, Tsuyoshi MIURA, Tetsurou WATADANI, Namgi HONG

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Keywords: Synthesis, Resolving agent, Optical resolution, Diastereomeric salt, Optical activity, R or S-Tartranilic acid, R or S-2-Phenoxypropionic acid, R or S-1-Benzylamino-3-phenoxy-2-propanol, Industrial use

JOURNAL FREE ACCESS

1998 Volume 56 Issue 9 Pages 773-780

DOI https://doi.org/10.5059/yukigoseikyokaishi.56.773

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Abstract

To date, the resolution of racemic mixture via diastereomeric salt formation has been the most commonly used industrial technique.
We have synthesized and applied new resolving agents for industrial application. Practical approach to the developments is as follows. Optically active 2-phenoxypropionic acid and tartranilic acid are readily employed for the resolution of bases, and 1-benzylamino-3-phenoxy-2-propanol for the resolution of acids.

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