Analytical Methods for Combinatorial Synthesis

Abstract

Analytical methods for solid phase synthesis are discussed. The advent of combinatorial organic synthesis has accelerated the development of reliable, rapid and sensitive analytical methods for solid phase organic synthesis. Classical colorimetric assays and spectrophotometric-based quantification methods for peptide synthesis are extended to solid phase organic synthesis. The analytical methods familiar to solution-phase synthesis, such as IR spectroscopy, mass spectroscopy, NMR spectroscopy are rapidly adapted for the analysis of solid phase synthesis.