金属錯体型人工DNA
DNA構造制御と金属錯体のナノ集積化
2004 年 62 巻 5 号 p. 508-513
詳細
2004 年 62 巻 5 号 p. 508-513
DNA has a structural basis for the “bottom-up” fabrication of functionalized molecular building blocks. In particular, the replacement of hydrogen-bonded DNA base pairing for alternative one would lead to a novel tool for re-engineering DNA. Recently, we have synthesized a series of artificial nucleosides bearing metal ligands instead of natural nucleobases and demonstrated that metal complexation between the nucleosides effectively drives base pairing. This review describes our recent approaches to metal-based strategy directed towards self-assembled metal arrays within DNA as well as towards structural control of DNA. This strategy provides a new method for self-assembled metal arrays in a predesigned fashion, leading possibly to metal-based molecular devices such as molecular magnets and wires.
