My Researches in National Institutes of Health

Abstract

Here I report my projects at Dr. Jacobson's laboratory in National Institutes of Health. Conformationally locked nucleotides, N-methanocarba analogs and oxabicyclo [2, 2, 1] heptane analog, were prepared for hP2Y₁ receptor. The most potent molecule is an N-methanocarba N⁶-methyl-2-iodo analogue (MRS-2500), which is the most potent antagonist selective for the P2Y₁ receptor yet reported. I also succeeded in identifying the pairs of neoceptor-neoligand, which are pharmacologically orthogonal with respect to the native species.