高度に歪んだパラシクロファン骨格を有する八オウアミン類の合成研究
2008 年 66 巻 4 号 p. 387-388
詳細
2008 年 66 巻 4 号 p. 387-388
Recent development of synthetic studies on novel marine alkaloids, haouamine A and B, is described. Haouamines have attracted considerable attention of synthetic chemists because of their unique structure and selective activity against human colon carcinoma cell line HT-29, however, only two groups have so far reported successful formation of their highly strained 3-aza-[7]-paracyclophane core. This review focuses on synthetic efforts to construct the core skeleton of haouamines reported by Baran and Wipf.
