Synthesis of Sialic Acid Derivatives Having Inhibitory Activities against Human Parainfluenza Virus Type 1

Abstract

Sialic acids are involved in a number of biological processes including cell-to-cell, cell-to-microorganism, -toxin, and -antibody binding. Among the diverse arrays of compounds related to sialic acid family, 2-deoxy-2, 3-didehydro-N-acetylneuraminic acids (Neu 5Ac2en) have been known as an inhibitor of sialidase, a key enzyme responsible for propagation of the influenza virus, occupying its important position in the modern medicinal chemistry. Human parainfluenza virus type 1 (hPIV-1) is a serious human pathogen causing upper and lower respiratory disease and is known to be a cause of croup in infants and young children. This article reviews our progress of the synthesis of Neu5Ac2en analogs and their biological evaluations against hPIV-1 sialidase.