Fifty years after the publication of
The Principles of Humane Experimental Technique by W.M.S. Russell and R.L. Burch there is a heightened interest in the development and application of
in vitro methods. The reasons behind this interest in new toxicological methods are numerous. Some are grounded in legislative bans on animal testing, such as the European Union's 7
th Amendment to the Cosmetics Directive which prohibits the use of animals to assess the safety of cosmetics and their ingredients. Others are due to the need for a pragmatic approach to large legislated testing programs such as the EU's Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) program. Without the use of
in vitro methods it is unlikely that all the proposed toxicity testing could be completed. Other reasons behind the new interest are due to ethical concerns - either by consumers who wish to purchase products they feel support their moral views about the use of animals, or by toxicologists themselves who feel strongly that non-animal methods should be used whenever possible.
One of the strongest drivers for the use of
in vitro methods is science itself. The need to understand the detailed mechanisms of toxicity have caused many researchers to adopt
in vitro methods. Advances in molecular and cellular biology in recent years have led to an unprecedented development of useful computational and cellular toxicology testing methods. These activities have recently been dramatically highlighted by a report from the US National Academy of Sciences' (NAS) report:
Toxicity Testing in the 21st Century: A Vision and a Strategy. The report clearly calls for a new toxicity testing strategy - one that relies on cell based methods which model toxicological pathways. The publication of this report has stirred interest in new toxicological approaches not only in the United States but throughout the world. It has helped to energize numerous organizations and societies working in the area.…
抄録全体を表示