Curcuma drugs are derived from the rhizomes of Curcuma plants, such as C. aeruginosa, C. aromatica, C. heyneana, C. longa, C. mangga, C. phaeocaulis, C. xanthorrhiza and C. zedoaria. They have been used as a spice, as a dye for textiles, as a major ingredient of curry powder and as a drug in traditional medicine, in many Asian countries. In Japan, Curcuma drugs derived from C. longa have been used to strengthen and tone the stomach, and the drug derived from C. zedoaria has been used to relieve the symptoms of “Oketsu” (various syndromes caused by the obstruction of blood circulation such as arthralgia, psychataxia and dysmenorrhea). In Indonesia, many Curcuma plants, such as C. xanthorrhiza (Temulawak), C. longa (Kunyit), are more commonly used in traditional Jamu medicine. The composition of the chemical constituents of Curcuma drugs often varies depending on the species, the geographical location, the cultivation conditions, and the post-harvest processing. In the present study, to evaluate the qualities of the Curcuma drugs produced in several countries in Asia, the chemical profiles of their constituents were investigated. As a result, it was shown that C. longa produced in Indonesia has the highest concentration of curcumin, which is one of the major active constituents in Curcuma drugs. Concerning the volatile constituents, C. longa and C. xanthorrhiza were characterized by high contents of bisabolane-type sesquiterpenes. Characteristic distributions of the sesquiterpenes, curzerenone, curdione, curcumenol and γ-bicyclohomofarnesal appeared in the chemical profiles of C. aeruginosa, C. heyneana, C. mangga, C. zedoaria, C. phaeocaulis, and C. aromatica. The following marker compounds of C. heyneana were identified; curcumanolide A and B, procurcumenol, 15, 16-bisnorlabda-8 (17),11-diene-13-one, zedoarondiol, isozedoarondiol and aerugidiol.
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