Histological View In this experiment I found intensely diffus basophilic cell irfiltration and muscle fiber degeneration in myocardium compared with those of the control. The most remarkable change in myocardium was perivascular granuloma, so called rheumatoid or tuberculoid, which consisted of basophilic cell infiltration, including plasma cell, and being accompanied with fibrous scar. Therein I could not find typical tubercles, of course such as LANGHAN's giant cells and caseous lesions. In the lung tissue were found epitheloid cell nodules and desquamative pneumonia, and in the testicles many typical tubercles and caseous lesions, but these changes made no essential differences compared with the control. In the other organs, such as liver, spleen, kidney and etc. were found a few tuberculous nodules without giant cells and caseous lesions but these changes were very slight compared with myocardial lesions.

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In the histological observations, I found allergic perivascular granuloma (KLINGE's granuloma) and diffus interstitial myocarditis in the heart. On the other hand in the lung I found only slight perivascular cell infiltration and intimal and medial fibrinoid swelling of small arteries and there-in I could find neither perivascular granuloma nor allergic pneumonia. In the other organs, such as liver, spleen, kidney and etc. there were no specific changes.

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The author investigated the reaction of circulatory system when large quantity of salt was given to normal rabbits, and showed following results and conclusion: (1) Reabsorption of salt decreases when large quantity of salt is given. (2) In addition to this there are the other two types of reaction which compensated one another, i. e. increase of blood volume and increase of blood velocity: the former goes with increase of blood depot, the latter with decrease of it. (3) when normal rabbits are given salt less than 2g. the former i .e. increase of blood volume predominates and when given more than 4g. the latter does.

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1). In this paper we reported some fundamental relationships between the vectorcardiogram and the unipolar electrocardiogram when they concerned with electric sources of various types, such as the electric dipole, electric double layer or dipolar electric source of wide pole-distance. The VCG and unipolar ECG used for these purposes were all calculative ones. The application of these calculative results for practical use will require the experimental proofs of the correctness of their findings. When the electric dipole or the double layer is concerned in electric source, we have not yet the way to demonstrate the correctness of these calculative results, for they are hypothetical ones. But, if the results of calculations in the fields of electric sources of many other types were coincident well with those of experiments, we may treat the calculative results as reliable ones even in the field of electric dipoles or electric double layers, because the calculations are made following the same principle governing the potential distribution in electro-static field or stational current field. The correctness of these calculations in the field of electric source of wide pole-distance or of many other types was proved experimentally well enough to be able to apply them for practical use in our previous reports. So, the results of these calculattions in this paper may be treated as useful ones in any case of electric source. 2). We found that we could imagine not only the magnitude and the direction but also the position of electric source in volume conductor from the relationship between the VCG and unipolar ECG. 3). Consequently arrised that we could analyse the activation process of human ventricles by using the VCG and unipolar ECG in conbination. For these purposes it is desirable to use the VCG having as little deformation as possible. 4). Strictly speaking, the unipolar ECG could not be the simple scalar projection of VCG on the line connecting the leading point to isoelectric center in the heart as Lasser, Grishman and others have said, except such a specific case that distant from every point to lead. 5). In major aspect, but, the unipolar tracing was deflected in positive side when the loop of VCG was recorded in the near side of isoelectric center to the leading point and was deflected in the negative side when it recorded in remote side. But their relationships were not so simple as scalar projection in geometrical sense. 6). An example of each VCG by mean of polyography and cube-system method and of each ECG of standard unipolar and bipolar extremity lead and standard unipolar chest lead of normal adult was obtained by calculation basing on a certain process of ventricular activation. Such a method to construct the ECG in various leads and the VCG of three planes reversely from heart model by calculation may be valuable for criticism of doublet theory and other interpretaions on electrical phenomena of heart. 7). The unipolar chest lead ECG by mean of Wilson's zero-potential electrode showed little difference from that of absolute potential variation, but the unipolar extremity lead ECG by meand of Wilson's method differed in relatively high grade from that. These differences between the unipolar ECG of Wilson's method and absolute potential variation may be the critical data for discussion of the reliability of zero-potential electrode by Wilson at present having no profitable method to criticize it.

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Wir berichten uber die elektrokardiographischen Veranderungen im ganzen Verlauf der 16 Falle (darunter 12 Falle spontan infizierte, 4 Falle kunstlich geimpfte) von Tsutsugamushi-patienten, und im folgenden: 1) Ein Fall zeigte die Niederspannung, die wahrscheinlich nicht durch die Tsutsugamushi-Krankheit hervorgerufen worden ist. 2) Bei 2 Fallen traten die Abwechslungen der Typen im ihren Verlauf auf. 3) Die intraaurikularen Reizleitungsstorungen erschienen bei 5 Fallen im Fieberstadium und bei 4 Fallen im fieberlosen Stadium, aber samtliche Falle im fieberlosen Stadium waren dieselben Falle wie im Fieberstadium. 4) Ein Fall zeigte den inkompletten atrioventrikularen Block I. Typus nach Dressler im Fieberstadium, und verschwand im fieberlosen Stadium. 5) Die intraventrikulare Reizleitungsstorungen erschienen bei 5 Fallen im Fieberstadium und bei 4 Fallen im fieberlosen Stadium, aber davon 3 Falle im fieberlosen Stadium waren dieslbe Falle wie im Fieberstadium. 6) Bei 3 Fallen trat die abnorme Verkurzung von Q-T im Fieberstadium auf, aber wurde normal im fieberlosen Stadium. 7) Die Muskelschadigung erschien bei 8 Fallen im Fieberstadium und bei 4 Fallen fieberlosen Stadium, davon 2 Falle im fieberlosen Stadium waren dieselbe Falle wie im Fieberstadium. 8) Die Sinustachykardie erschien bei 4 Fallen im Fieberstadium und auch die Sinusbradykardie trat bei 1 Fall im Fieberstadium und bei 3 Fallen im fieberlosen Stadium auf. 9) Ein Fall zeigte die Sinusarrhythmie uber 15% im Fieberstadium. 10) Bei 3 Fallen zeigten niemals die Veranderungen im ganzen Verlauf, die Veranderungen, die in Fieberstadium auftraten, verschwanden bei 3 Fallen im fieberlosen Stadium, und bei 2 Fallen in demselben Fieberstadium. Auch die Veranderungen, die im Fieberstadium auftraten, erleichterten sich bei 6 Fallen im fieberlosen Stadium, und waren bei 2 Fallen im ganzen Verlauf gleichartig.-d. h. verschwanden oder erleichterten sich die Veranderungen bald darauf in dem meisten Fallen. 11) Die elektrokardiographischen Veranderungen waren in meisten Fallen bei der Tsutsugamushi-Krankheit vorubergehend und sogar nicht ernst. 12) Wir nehmen an, dass die Ursache der elektrokardiographischen Veranderungen bei der Tsutsugamushi-Krankheit wahrscheinlich nicht durch die primare Herzschadigung hervorgerufen worden ist.

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