International Heart Journal
3,592 registered articles
(updated on May 28, 2022)
Online ISSN : 1349-3299
Print ISSN : 1349-2365
ISSN-L : 1349-2365
1.826
2020 Journal Impact Factor (JIF)
JOURNAL PEER REVIEWED FREE ACCESS ADVANCE PUBLICATION
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Featured article
Volume 63 (2022) Issue 2 Pages 398-403
Oral Adrenergic Agents Produced Ventricular Fibrillation and QT Prolongation in an Elderly Patient Carrying an RYR2 Variant
Kanae Hasegawa, Jingshan Gao, Seiko Ohno, Kentaro Ishida, Shinsuke Miyazaki, Takeru Makiyama, Minoru Horie, Hiroyasu Uzui, Hiroshi Tada

Mutant cardiac ryanodine receptor channels (RyR2) are "leaky," and spontaneous Ca2+ release through these channels causes delayed afterdepolarizations that can deteriorate into ventricular fibrillation. Some patients carrying RYR2 mutations in type 1 catecholaminergic polymorphic ventricular tachycardia exhibit QT prolongation and are initially diagnosed with long QT syndrome. However, none have been reported to cause drug-induced ventricular fibrillation in patients with RYR2 variants. We describe the first case of an elderly woman with drug-induced QT prolongation and ventricular fibrillation who carried a novel RYR2 variant but no other mutations related to long QT syndrome. Oral adrenergic agents might induce QT prolongation and subsequent ventricular fibrillation in patients carrying an RYR2 variant. Screening for RYR2 could be valuable in patients with suspected drug-induced long QT syndrome.
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Announcements from publisher
  • The number of tables/figures/references is limited, and it might be charged an additional cost. See details at Information for Authors.
  • The final version of manuscripts submitted in October 2019 and later will be subject to a JPY150,000 publication fee. The fee will be payable after the final version of the manuscript is accepted for publication in International Heart Journal.
  • ”Information for Authors” has been changed. Please read it before submission, especially in case of "Case Report".
Predecessor

Japanese Heart Journal

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