International Heart Journal

Featured article

Volume 60 (2019) Issue 2 Pages 241-246

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Masaya Sakamoto, Daisuke Matsutani, Yosuke Kayama

The evaluation of baroreflex sensitivity (BRS), which maintains systemic circulatory homeostasis, is an established tool to assess cardiovascular autonomic neuropathy in type 2 diabetes mellitus (T2DM). As BRS plays an important function in blood pressure regulation, reduced BRS leads to an increase in blood pressure variability, which further leads to reduced BRS. This sequence of events becomes a vicious cycle. The major risk factors for reduced BRS are T2DM and essential hypertension, but many other risk factors have been reported to influence BRS. In recent years, reports have indicated that glycemic variability (GV), such as short- and long-term GV that are considered important risk factors for macrovascular and microvascular complications, is involved in reductions in BRS independently of blood glucose levels. In this review, we discuss reduced BRS in T2DM, its features, and the potential for its reversal.

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2019 Volume 60 Issue 2

Changes in Autophagy Levels in Rat Myocardium During Exercise Preconditioning-Initiated Cardioprotective Effects Ji-Yong Li, Shan-Shan Pan, Jia-Yin Wang, Jiao Lu
Intravenous Immunoglobulin Therapy for Acute Myocarditis in Children and Adults Xin Huang, Yufei Sun, Guanhua Su, Yu Li, Xinxin Shuai
Right Heart is a Key to Response to Adaptive Servo-Ventilation Therapy Teruhiko Imamura
Atrial Septal Defect of the Ostium Secundum Type in A 101-Year-Old Patient Takahiro Matsumoto, Eiji Tamiya, Tatsuji Kanoh, Tomosato Takabe, Ken-ichi Kuremoto, Takashi Kamiyama, Shoichi Yamamoto, Hiroyuki Daida

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