International Heart Journal

Featured article

Volume 60 (2019) Issue 2 Pages 241-246

Clinical Implications of Baroreflex Sensitivity in Type 2 Diabetes

Masaya Sakamoto, Daisuke Matsutani, Yosuke Kayama

The evaluation of baroreflex sensitivity (BRS), which maintains systemic circulatory homeostasis, is an established tool to assess cardiovascular autonomic neuropathy in type 2 diabetes mellitus (T2DM). As BRS plays an important function in blood pressure regulation, reduced BRS leads to an increase in blood pressure variability, which further leads to reduced BRS. This sequence of events becomes a vicious cycle. The major risk factors for reduced BRS are T2DM and essential hypertension, but many other risk factors have been reported to influence BRS. In recent years, reports have indicated that glycemic variability (GV), such as short- and long-term GV that are considered important risk factors for macrovascular and microvascular complications, is involved in reductions in BRS independently of blood glucose levels. In this review, we discuss reduced BRS in T2DM, its features, and the potential for its reversal.

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2019 Volume 60 Issue 2

Assessment of Unicuspid Aortic Valve Stenosis Using Multimodality Imaging, X-ray Radiography and Raman Analysis Hsiao-Huang Chang, Ching-Li Cheng, Wei-Chen Wang, Pei-Jung Huang, Shan-Yang Lin
Osteopontin in the Pathogenesis of Aortic Dissection by the Enhancement of MMP Expressions Fudong Fan, Qing Zhou, Zhenjun Xu, Dongjin Wang
Rare Simultaneous Left and Right-Sided Native Valve Infective Endocarditis Caused by Rare Bacterium Jian-Hong Pan
Independent Prognostic Value of Pulmonary Diffusing Capacity in Nonsmoking Patients with Chronic Heart Failure Kenji Nakamura, Hideaki Kanzaki, Atsushi Okada, Makoto Amaki, Hiroyuki Takahama, Takuya Hasegawa, Yasuo Sugano, Satoshi Yasuda, Toshihisa Anzai

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