The causes of limb amputation include trauma and disease (tumor, infection, peripheral circulatory disturbance, congenital disease). In recent years, the number of amputees has increased along with the increase in diseases caused by diabetes and arteriosclerosis. Rehabilitation after amputation varies depending on the site of amputation, age, cause of amputation, goal setting, etc., but amputees aim to be able to live in a state that is as close to pre-amputation as possible. It is necessary to perform rehabilitation including joint range of motion training, and creation of prosthetic limbs. In addition, rehabilitation aiming at the long-term support and improvement of athletic ability is also necessary because of not only returning to daily life and work, but also returning to sports and playing sports for disabled people. On the other hand, KAATSU training is a novel training under moderate blood flow restriction, but it is completely different from tourniquet or hemostasis. KAATSU training is expected to increase muscle strength and mass even with a light load. And, combining KAATSU method can be expected to make it easier to gain muscle strength and mass even in situations where load cannot be applied or when the limbs are shortened in the case of amputation. In this paper, we outline rehabilitation after amputation and the application of KAATSU training, including our experiences in the United States.