-
Hikaru YOKOTA, Akinori YANAKA, Hiroshi MUTO
1991 Volume 30 Issue 2 Pages
103-107
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
To investigate the role of the mucus-bicarbonate barrier in the prevention of duodenal ulcer recurrence, duodenal mucosal neutralizing capacity and mucosal prostaglandin (PG) synthesis were examined in 5 normal controls (NC) and 12 duodenal ulcer (DU) patients. DU patients were divided into non-recurrent (NR, 7) and recurrent (R, 5) groups based on endoscopic follow-up study. The recovery time (RT) was significantly longer and the mucosal PGE
2 synthesis was significantly lower in R than in NC and NR groups. There was a proportional correlation between mucosal PG synthesis and RT in DU patients. These results indicate that impaired neutralizing capacity caused by reduced endogenous PG synthesis in duodenal mucosa may contribute to recurrence of DU.
View full abstract
-
Moritaka SUGA, Masayuki ANDO, Hiroshi NlSHlKAWA, Shukuro ARAKI
1991 Volume 30 Issue 2 Pages
108-112
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Adenosine deaminase (ADA) activity and free interleukin (IL)-2 receptor levels were assayed in serum samples from patients with mycoplasma and bacterial pneumonia to evaluate the usefulness of these parameters in distinguishing between these diseases at an early stage. Serum ADA and free IL-2 receptor levels in patients with mycoplasma pneumonia (32.4±9.2 U/l, 960±204 U/ml) were significantly higher than those in patients with bacterial pneumonia (12.5±3.3 U/l, 425±86 U/ml) and in healthy controls (14.0±3.4 U/l, 286±49 U/ml) (p<0.001). Of the 20 mycoplasma pneumonia cases, 19 showed increased levels of ADA over 20.8 U/l; in 17 of the 19, the increase of ADA was seen before the elevation of the specific antibody to
Mycoplasma pneumoniae. In contrast, serum ADA levels in all 20 cases of bacterial pneumonia were lower than 20.8 U/l. These results indicate that assays for serum ADA and free IL-2 receptor levels are useful in distinguishing between bacterial and mycoplasma pneumonia at an early stage.
View full abstract
-
Fumitaka OGUSHI, Saburo SONE, Sukh M. SINGH, Kenji TANI, Toshio OZAKI, ...
1991 Volume 30 Issue 2 Pages
113-117
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8±0.9 U/ml and 0.1±0.1 U/ml, respectively (p<0.01). A slight correlation was found between the soluble IL-2R level and the number of CD4-positive cells. Sarcoidosis patients were classified by radiographical staging. Soluble IL-2R was not detectable in the BALF of any stage I patients, but was found in the BALF of 6 of the 7 stage II and stage III patients. These results suggest that in the clinical management of patients with sarcoidosis, measurement of soluble IL-2R in BALF is useful for evaluating the activity of the lung disease is sarcoidosis.
View full abstract
-
Shigeru ARAGA, Hiroshi KAGIMOTO, Akiko ADACHI, Koji FUNAMOTO, Kazuhiko ...
1991 Volume 30 Issue 2 Pages
118-122
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
The kappa/lambda (κ/λ) ratios of IgG, IgA and IgM in the cerebrospinal fluid (CSF) and in the sera of 10 patients with Guillain-Barré syndrome were analyzed. The κ/λ ratios of IgG, IgA and IgM in the CSF and in the serum were not significantly different between the acute and the late stages of Guillain-Barré syndrome nor between Guillain-Barré syndrome and the normal controls. In the CSF, however, the concentration of albumin, IgG, IgA and IgM in the acute phases of Guillain-Barré syndrome were significantly higher than in the normal controls. These results suggest that in Guillain-Barré syndrome, the increase of immunoglobulins may not be due to intrathecal synthesis and therefore there are no significant changes in the κ/λ ratios in the CSF.
View full abstract
-
Kazuo SUZUKI, Yuhji MURATA, Kazuharu SHIOTANI, Makoto KUNIKANE, Shinsa ...
1991 Volume 30 Issue 2 Pages
123-129
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 43-year-old male with non-Hodgkin's lymphoma accompanied by autoimmune hemolytic anemia (AIHA). His blood group was group B, CcDEe. Alloantibody was absent in his serum, but autoantibody, a combination of IgG and C3d type which showed anti-e specificity, was present. Although transient improvement of AIHA was achieved by treatment with 60 mg/day of prednisolone, subsequent worsening of the anemia resulted in the patient's death. Identification of blood group-specific autoantibodies may be beneficial in such a case for blood transfusion.
View full abstract
-
Hiroshi HIROSE, Yuzuru TAKEMURA, Satoki HONMA, Koichiro ASANO, Toshio ...
1991 Volume 30 Issue 2 Pages
130-134
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 67-year-old woman was admitted for nephrotic syndrome. In spite of the lack of lymphadenopathy, hepatosplenomegaly and serum hyperviscosity, remarkable monoclonal IgM-proteinemia was demonstrated. Amyloid kidney was shown by renal biopsy. However, in the bone marrow and other organs, neither proliferation nor invasion of monoclonal immunoglobulin-producing cells was revealed by immunohistological investigations of the specimens biopsied or examined at autopsy, excluding Waldenström's macroglobulinemia. Immunosuppressive chemotherapy with cyclophosphamide, vincristine and prednisolone was effective in reducing serum IgM, but could not slow the progression of renal failure. This case suggested the association of generalized amyloidosis with excessive IgM-proteinemia caused by a non-malignant mechanism.
View full abstract
-
Katsunori SHIGEHARA, Kouji TAKAHASHI, Kazunori TSUNEMATSU, Hiroyuki KO ...
1991 Volume 30 Issue 2 Pages
135-137
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Fungal infections are often reported, but Trichosporon infection is very rare. A 78-year-old man with adult T-cell leukemia complicated with pulmonary infections is presented. Bronchial exudate culture revealed many yeast-like colonies, which were morphologically and biochemically identified as
Trichosporon pullulans.
View full abstract
-
Kousuke ASAGOE, Sumire YAMAGUCHI, Hiroto SAKODA, Bunichiro KISHINO, Hi ...
1991 Volume 30 Issue 2 Pages
138-141
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 71-year-old female visited our outpatient unit with chief complaints of anorexia and a sense of abdominal distension. The abnormalities found after admission were conspicious increases in CA125 levels in serum and ascites as well as anemia, accelerated erythrocyte sedimentation and increased serum LDH. The patient underwent an emergency operation for ileus. The histological diagnosis was serous papillomatous cancer. Immunohistologic staining of the cancer tissue demonstrated the production of CA125. In this very rare the remnant of the Müllerian duct in the peritoneum is thought to have been cancerous.
View full abstract
-
Takayuki YAMAGUCHI, Yuzo SHIMIZU, Naomi ONO, Masazumi UNNO, Hideo NISH ...
1991 Volume 30 Issue 2 Pages
142-145
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A patient with subarachnoid hemorrhage who exhibited changes suggestive of myocardial infarction by electro- and echocardiography and underwent coronary angiography is reported. Echocardiography demonstrated marked hypokinesis in the left ventricular anterior wall to the septum. Since the possibility of concomitant myocardial infarction could not be excluded, coronary angiography was performed with cerebral angiography. No abnormalities were observed in the coronary arteries, and the myocardial damage was considered to be due to subarachnoid hemorrhage. Echocardiograms showed improvements in left ventricular wall motion within a short time after operation of the intracranial lesion.
View full abstract
-
Takanobu WAKASUGI, Takahiko AOYAMA, Jun-ichi HIRAI, Takashi SAGA
1991 Volume 30 Issue 2 Pages
146-153
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
The proband, a 42-year-old woman without any symptoms or hypertension, was admitted for examination of accidentally discovered bilateral adrenal masses. Physical examination disclosed bilateral nodular goiter and mild sinus tachycardia. Pheochromocytomas and medullary thyroid carcinomas were revealed by biochemical and histopathological examinations. Hypercholesterolemia and abnormal glucose metabolism returned to normal after bilateral total adrenalectomy and thyroidectomy. Screening examination showed four affected family members. Three of them were also asymptomatic and normotensive. In pheochromocytoma patients, normotension, hypercholesterolemia, and impaired glucose metabolism might be signs of excess secretion of epinephrine rather than norepinephrine.
View full abstract
-
Tomoyuki KIDO, Yoshikazu NAKATA, Kazuko AOKI, Naoshige HATA, Shuji HAZ ...
1991 Volume 30 Issue 2 Pages
154-156
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A case of infective endocarditis of the tricuspid valve is described in a young female patient with no history of intravenous drug abuse. The patient suffered from symptoms of septic emboli of the lung and right heart failure. She was ultimately treated by tricuspid valve replacement. There was no recurrence of symptoms following surgery.
View full abstract
-
Fumio OMATA, Yukinobu ICHIKAWA, Hiroyuki NOZAKI, Haruo NOMOTO, Shigeru ...
1991 Volume 30 Issue 2 Pages
157-160
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Factor V deficiency associated with rheumatoid arthritis was found in a 54-year-old woman. Hereditary factor V deficiency is very rare; only about 150 cases have been reported since its discovery in 1943. This appears to be the first case report of factor V deficiency associated with rheumatoid arthritis in the literature.
View full abstract
-
Toshio HAMADA, Kaoru OHSHIMA, Yoshihiko IDE, Shunichi SAKATO, Masaharu ...
1991 Volume 30 Issue 2 Pages
161-163
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 45-year-old woman presented with persistent headache which was of acute onset and occurred daily. Laboratory findings included thrombocytosis, elevated levels of antinuclear antibody, rheumatoid factor, and antibodies to Epstein-Barr virus (EBV). Magnetic resonance image of the head, left selective external carotid angiography, temporal arterial biopsy, and cerebrospinal fluid revealed no abnormal findings that could explain her headache. Her headache was compatible with NDPH, which has been reported by Vanast, and was thought to be related to EBV reactivation.
View full abstract
-
Masanori KANATANI, Ryohji NAKAMURA, Keizo KUROKAWA, Masahiko TAODA, Yo ...
1991 Volume 30 Issue 2 Pages
164-169
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 70-year-old woman with Cogan's syndrome first presented with central diabetes insipidus and then developed secondary hypothyroidism. Magnetic resonance imaging revealed a diffuse pituitary swelling without evidence of tumor. High-dose glucocorticoid therapy administered to treat Cogan's syndrome was very effective in suppressing the inflammatory process, and resulted in the reversal of the pituitary swelling and partial recovery of thyroid stimulating hormone secretion. This is the first case of hypopituitarism associated with Cogan's syndrome, a form of autoimmune vasculitis. The glucocorticoid-responsive pituitary lesion is best explained by autoimmune hypophysitis which shows pituitary swelling and is known to often associate with other autoimmune phenomena.
View full abstract
-
Tsugiyasu KANDA, Shigeru OHSHIMA, Kazuo YUASA, Takuji TOYAMA, Shin-ich ...
1991 Volume 30 Issue 2 Pages
170-174
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A pair of 37-year-old identical twins with diabetes mellitus are described. One of the brothers was admitted for heart failure without pain, and autonomic neuropathy was found. The clinical diagnosis was inferior myocardial infarction with anteroseptal healed myocardial infarction. Cardiac catheterization revealed triple coronary vessel involvement. The diagnosis was confirmed at autopsy after sudden death. The other brother was also examined by cardiac catheterization, which revealed total right coronary occlusion and hypokinesis of the wall. There had been no previous pain nor upper body discomfort until that time in either twin. Thus, genetic factors should possibly be considered in the genesis of asymptomatic or silent myocardial infarction.
View full abstract
-
Shuji YONEKURA, Tadami NAGAO, Shigeru ARIMORI
1991 Volume 30 Issue 2 Pages
175-178
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Literature reviews have indicated that thrombotic complications in leukemic patients are rare that prompt diagnosis is very difficult, and that morbidity and mortality are extremely high. We describe the successful treatment of a 36-year-old housewife suffering from chronic myelogenous leukemia with secondary myelofibrosis.
View full abstract
-
Yasuyoshi YAMAJI, Matsuhiko HAYASHI, Yutaka SUZUKI, Kumiko NOYA, Osami ...
1991 Volume 30 Issue 2 Pages
179-181
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
A 30-year-old woman with thyroid crisis and impaired renal function presented with severe hypocalcemia. She had already had hypocalcemia one yr previously when her serum creatinine level was normal. A normal level of serum amino terminal fragment of parathyroid hormone in spite of severe hypocalcemia suggested impairment of parathyroid function. Since her serum magnesium was normal and she had no history of neck surgery or radioiodine therapy, her hypoparathyroidism was considered to be idiopathic. This is the seventh case with co-existing Graves' disease and idiopathic hypoparathyroidism reported in the literature.
View full abstract
-
Masanori NAKAGAWA, Akinori NAKAMURA, Ryuji KUBOTA, Tomokazu KAKAZU, Mu ...
1991 Volume 30 Issue 2 Pages
182-188
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
Twocases of necrotizing myelopathy, one with lung carcinoma and the other with adult T cell leukemia (ATL), displayed flaccid paraplegia and sphincter dysfunction. Both cases did not show any direct neoplastic cell invasion of the spinal cord. Pathologically, diffuse and random necrosis was found in the spinal cord in both cases. In the case of ATL, small numbers of inclusion bodies in the nerve cell nuclei were demonstrated. Using polyclonal and also monoclonal antibodies, herpes simplex virus type 2 (HSV-2) was clearly demonstrated in the spinal cord in both cases. By electron microscopy, numerous herpes virus particles were observed in the spinal cord in both cases. The usefulness of electrophysiological studies should be emphasized in the differentiation of these cases from others which might also display flaccid paraplegia. The possibility of necrotizing myelopathy caused by HSV-2 should always be considered in the differential diagnosis of spinal cord diseases displaying flaccid paraplegia.
View full abstract
-
Jiro FUJIYAMA, Masaru KURIYAMA, Hiroaki YOSHIDOME, Masahito SUEHARA, N ...
1991 Volume 30 Issue 2 Pages
189-192
Published: 1991
Released on J-STAGE: March 27, 2006
JOURNAL
FREE ACCESS
This report describes a case of cerebrotendinous xanthomatosis (CTX) accompanied by clinical manifestations of parkinsonism, including oily and masked face, marked akinesia, muscle rigidity and resting hand tremor. Magnetic resonance imaging (MRI) of the brain showed high intensity areas on T2 weighted imaging, and slightly low intensity areas on T1 weighted imaging in the right globus pallidus and the left putamen. Cerebral cortical atrophy with slight ventricular dilatation and cerebellar atrophy were present as well. This is a case report of CTX which manifested parkinsonism. Parkinsonism may not be a coincidental manifestation in CTX, but rather represent a symptom of the same underlying diathesis.
View full abstract