A general mechanism is proposed, capable of accounting for both the stimulating action of visible and infrared lasers on cell cultures, at low laser doses, and the damaging action at larger doses. Laser irradiation is assumed to intensify the formation of a trans-membrane electrochemical proton gradient in mitochondria, This enhances ATP production which activates the Ca
2+ pumps. depleting the Ca
2+ concentration in the cytoplasm and increasing the Ca
2+ concentration gradient of the surrounding medium relative to the cytoplasm. This triggers enhanced Ca
2+ influx into the cells via the Ca
2+ ion channels of the cell membrane. In addition, with sufficient irradiation, the proton-motive force (pmf), due to the proton gradient, causes more Ca
2+ to be released from the mitochondria by an ‘antiport ’ process. The additional calcium transported into the cytoplasm, together with other factors controlled by the pmf triggers mitosis and enhances cell proliferation. At higher laser doses, too much Ca
2+ is released. This causes hyperactivity of Ca
2+-ATPase and exhausts the ATP reserves of the cell. The nature of the photoacceptors and possible ways in which the visible and infrared laser energy is converted by the photoacceptors are discussed,
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