To evaluate the correlation between serum and paritoneal lavage fluid (PLF) cytokines and the clinical severity of patients diagnosed with acute abdomen. Methods: Subjects numbered 16-13diagnosed with digestive tract perforation and 3 with strangulating bowel obstruction. Of the 13 with perforation, 9 involved the upper digestive and 4 the lower digestive tract. Blood samples and PLF were collected immediately after laparotomy. TNFα, IFN-γ, IL-6, and IL-10 concentration in serum and PLF were measured by enzymelinked immunosorbent assay. Clinical status was analyzed based on systemic inflammatory response syndrome (SIRS) criteria. Results: Five of the 9 with upper digestive and all 4 with lower digestive tract perforation met SIRS criteria. Serum IL-10 in those with lower digestive tract perforation was significantly higher than in those with upper digestive tract perforation. PLF IL-10 in those with SIRS was significantly higher than in those without SIRS. PLF IL-10 in those with SIRS 4 scores was significantly higher than in those with SIRS 2 or 3 scores. PLF IFNγin those with SIRS 4 scores was significantly lower than in those with SIRS 2 or 3 scores. Conclusions: PLF IL-10 and IFNγratios correlate positively with acute abdomen severity based on SIRS criteria.

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