Journal of Coronary Artery Disease
Online ISSN : 2434-2173
29 巻, 3 号
選択された号の論文の6件中1~6を表示しています
Review Articles
  • Shozo Sueda, Yasushi Fujiwara, Keisho Kurokawa, Tsukasa Kurokawa, Tomo ...
    2023 年 29 巻 3 号 p. 49-55
    発行日: 2023年
    公開日: 2023/09/25
    [早期公開] 公開日: 2023/08/07
    ジャーナル オープンアクセス
    Statin treatment improves endothelial dysfunction and decreases plaque volume in patients with obstructive coronary artery disease (OCAD) as a pleiotropic mechanism. Clinical outcomes in patients with OCAD under statin therapy are favorable compared with those outcomes for patients without statins. However, the effect of statins may be uncertain in patients with vasospastic angina and nonobstructive coronary artery disease (VSA-NOCAD). Several researchers in South Korea and Japan have reported on the effectiveness of statin therapy in patients with VSA-NOCAD. Flow-mediated dilatation was shown to be improved in VSA patients with statins compared with patients without statins. However, statin treatment was shown to not be effective in reducing the major cardiovascular events (MACEs) in patients with VSA-NOCAD, although after propensity score matching, the prognosis was better in patients with VSA-NOCAD. Furthermore, high-intensity statin therapy showed no clinical utility for mitigating MACEs in patients with VSA-NOCAD.
  • The Negative Impacts of Arteriovenous Fistulas and Microvascular Dysfunction
    Hiroyuki Nakajima, Yusuke Watanabe
    2023 年 29 巻 3 号 p. 56-61
    発行日: 2023年
    公開日: 2023/09/25
    ジャーナル オープンアクセス
    Coronary artery bypass grafting (CABG) is advantageous for long-term clinical outcomes compared to percutaneous coronary intervention (PCI) in hemodialysis (HD) patients, as PCI has a lower short-term mortality but higher late revascularization risk. Therefore, CABG is very important for HD patients in current clinical practice. In HD patients, the presence of an arteriovenous fistula may lower the flow capacity of the ipsilateral internal thoracic artery (ITA) and induce flow steal, and concomitant microvascular disease (MVD) can cause myocardial ischemia and irreversible myocardial damage even after CABG. The use of the ipsilateral ITA as a free graft or the contralateral ITA as a graft to the left anterior descending artery can be reasonable options. MVD complicates the preoperative evaluation and could worsen clinical outcomes in HD patients. Graft selection and MVD in coronary and systemic circulation are mutually influential future concerns.
Original Article
  • Hanae Sasaki, Ryosuke Kowatari, Norihiro Kondo, Masahito Minakawa
    2023 年 29 巻 3 号 p. 62-66
    発行日: 2023年
    公開日: 2023/09/25
    [早期公開] 公開日: 2023/07/31
    ジャーナル オープンアクセス
    Objective: Placing the internal thoracic artery (ITA) graft ipsilateral to the arteriovenous fistula (AVF) for left anterior descending artery (LAD) revascularization in coronary artery bypass grafting (CABG) in hemodialysis patients may cause coronary steal. However, whether or not ipsilateral or contralateral ITA grafts affect the flow volume and pulsatility index measured based on the transit time flow measurement of the ITA-LAD anastomosis is unclear.
    Materials and methods: Between January 2013 and December 2021, 52 hemodialysis patients who underwent CABG with ITA-LAD anastomosis were divided into two groups based on whether the ITA graft was implemented ipsilateral (n = 42) or contralateral (n = 10) to the AVF.
    Results: The average age at surgery and the duration of hemodialysis were 65.4 ± 8.4 years old and 82.5 ± 54.5 months in the ipsilateral group and 66.9 ± 9.0 years old and 68.8 ± 52.6 months in the contralateral group. There were no significant differences between the ipsilateral and contralateral groups in terms of LAD stenosis (87.4% ± 12.3% vs. 86.8% ± 15.2%), left ventricular ejection fraction (49.0% ± 15.0% vs. 46.7% ± 14.4%), operation time (376.7 ± 83.2 vs. 407.6 ± 117.5 min), intraoperative flow (40.3 ± 24.0 vs 38.5 ± 16.5 mL/min), and pulsatility index (2.7 ± 1.2 vs. 2.3 ± 0.6) for ITA-LAD. There was no graft occlusion on computed tomography in either group at two weeks postoperatively.
    Conclusions: Our study suggests that an ITA graft ipsilateral to the arteriovenous fistula may not always be contraindicated in hemodialysis patients and may be appropriate in most cases.
Case Reports
Imaging Case Report
feedback
Top