Rosai-Dorfman Disease (RDD) is characterized by histiocytic proliferation in the sinuses of affected mediastinal lymph nodes. We report a patient with fever of unknown origin (FUO) who was treated for secondary thrombotic microangiopathy (TMA)；however, postmortem histology revealed RDD. TMA was treated with 12 rounds of plasma-exchange therapy, but this was only partially effective. A hematological tumor (Castlemanʼs disease) was suspected and intravenous pulsed steroids and oral prednisolone therapy improved the patientʼ s general condition. Unfortunately, the patient died due to acute myocardial infarction. Postmortem analysis of paratracheal lymph adenopathy nodes revealed the proliferation of histiocytes exhibiting emperipolesis, characteristic of RDD.

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[in Japanese]

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A 50-year-old man was referred to us due to palpitation, sweating, and body weight loss. He had an enlarged thyroid with hyperthyroidism and was positive for anti-TSH receptor antibody, leading to diagnosis of Gravesʼ disease. He also showed an enlarged parotid, and cytology revealed myoepithelial cells with interstitial mucus, which was diagnostic for pleomorphic parotid adenoma.

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[in Japanese]

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[in Japanese]

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