A granular cell tumor is a rare neoplasm derived from Schwann cells that usually occurs on the tongue, skin, and subcutis. In the gastrointestinal tract, it is most commonly found in the esophagus. We report a case of a granular cell tumor originating from the subserosa of the small intestine in a 50-year-old woman. Computed tomography (CT) showed a well-demarcated, abdominal mass consisting of cystic and solid portions with moderate contrast enhancement and FDG accumulation (SUVmax: 5.0). The location of the tumor changed between CT and PET/CT, suggesting that it originated in the small intestine or mesentery. The differential diagnoses included various mesenchymal diseases such as gastrointestinal stromal tumor (GIST), solitary fibrous tumor (SFT), neurogenic tumor, and sarcoma. Laparoscopic resection of the tumor was performed, with the pathological diagnosis of granular cell tumor. Histologically malignant findings such as spindle-shaped cells, high nucleocytoplasmic ratio, and nuclear pleomorphism were observed. The standard treatment for malignant granular cell tumor has not been established due to the small number of cases. Since there was no distant metastasis in the present case, the patient was carefully monitored without additional treatment, and the tumor has not recurred or metastasized to date.

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A 44-year-old woman who underwent chest CT for a medical check-up presented with multiple nodules in both lungs. She had no specific symptoms. Some of the multiple pulmonary nodules on chest CT were associated with a cavity within the nodules. The multiple lung nodules were followed up with chest CT, but there was no change in size over 3 years. Video-assisted thoracic surgery was performed, and the diagnosis of minute pulmonary meningothelial-like nodules (MPMNs) was established by pathological examination. Recently, MPMNs have been in-creasingly discovered on chest CT. It is clinically problematic to discriminate MPMNs from multifocal micronodular pneumocyte hyperplasia (MMPH) or multiple Well-differentiated adenocarcinoma. When chest CT shows multiple pulmonary nodules in both lungs in patients with neither malignancy nor tuberous sclerosis, MPMNs should be considered. Multiple pulmonary lesions with a cavity may be more suggestive of MPMNs than MMPH.

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