Purpose: Left ventricular ejection fraction (LVEF) is commonly measured by echocardiography to evaluate LV function. However, LVEF does not necessarily reflect actual LV function. In fact, half of patients with heart failure have normal LVEF. On the other, plasma brain natriuretic peptide (BNP) is high in those patients and reflects the prognosis. The levels of plasma BNP are also reported to increase with age in subjects with normal LVEF. Therefore, we evaluated whether global function index (GFI)=E/E′/S′ changes with age like plasma BNP, and what factors contribute to the levels of GFI in subjects with normal LVEF.
Subjects and Methods: The study group included 770 patients with normal echocardiography (no organic abnormality). We measured GFI in addition to parameters measured in the routine study, and compared the value of GFI in each decade. Furthermore, we determined the independent factors affecting the levels of GFI by multivariable analysis.
Results: GFI increased with age like BNP (r=0.567, p<0.001). Multivariable analysis revealed that the high level of GFI was associated with left atrium size (odds ratio 1.050, 95%confidence interval(CI) 1.020-1.090), age (every 10 years) (odds ratio 2.650, 95%CI 2.070-3.410), male (odds ratio 0.386, 95%CI 0.249-0.598), hypertension (odds ratio 1.730, 95%CI 1.070-2.800), and diabetes mellitus (odds ratio 1.660, 95%CI 1.020-2.700).
Conclusion: These results suggest that GFI reflects the changes in LV function in subjects with preserved LVEF. Further study will be needed to clarify the importance of increased GFI with preserved LVEF.
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