Duocaine, which is a combination of 2 per cent procaine and 1.25 per cent butethamine with epinephrine 1:65, 000, was used with favorable results in the following minor and major oral surgery: 115 tooth extractions, 5 pulp exstirpations, 7 abscess incisions, 4 apicoectomies, 2 each of resection of the mandible and enucleation of cyst, one each of alveolectomia, plastic surgery of the lower lip and reduction of the mandible.
Particularly in case of tooth extraction about 80 per cent showed successful anesthetic effect within minutes after within 3 minutes after injection.
In addition, two comparative studidies of duocaine with xylocaine or procaine were made.
1. One cc each of duocaine and xylocaine or procaine was injected in the forearms and the anesthetized areas of the skin were measured and compared, as shown in Fig. 1.
2. The effect of these anesthetics upon the sciatic nerve of rana nigromaculata was compared in the nerve and muscle specimen, as shown in Figs. 2 and 3.
The results obtained in these expriments showed that duocaine has more favorable effect than procaine and has similar effect with xylocaine.(Authors' abstract)

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