Japanese Journal of Protozoology
Online ISSN : 2189-6747
Print ISSN : 0388-3752
ISSN-L : 0388-3752
Search
Advanced search
OR
Browse
Search
Volume 43, Issue 1
Displaying 1-2 of 2 articles from this issue
Show all abstracts
    • |<
    • <
    • 1
    • >
    • >|
Review
Short Communication
  • Identification of the Dictyostelium discoideum gene for a protein showing sequence similarity to iron superoxide dismutase
    Kosuke Nomoto, Yosuke Umeda, Jin-ichi Taniguchi, Takahiro Katayama, Hi ...
    2010 Volume 43 Issue 1 Pages 19-23
    Published: 2010
    Released on J-STAGE: August 01, 2016
    DOIhttps://doi.org/10.18980/jjprotozool.43.1_19
    JOURNAL FREE ACCESS
    Show abstractHide abstract
    Some protozoan parasites encode iron superoxide dismutase (FeSOD), but mammalians do not, and FeSOD is therefore an attractive target for drug therapy. Database screening revealed that the social amoeba Dictyostelium discoideum encodes a protein similar to FeSOD. Since D. discoideum is non-pathogenic and easy to main-tain in laboratory conditions, analysis of the protein would contribute to drug design and chemotherapy for infectious diseases. RT-PCR analysis showed that the gene for the protein was expressed at a high level in growing cells and at decreased levels in subsequent developmental stages. Fluorescence of green fluorescent protein fused with the N-terminal region (Met1 - Leu35) of the D. discoideum protein was detected in mitochondria, indicating that the protein is localized in mitochondria.
    View full abstract
    Download PDF (1019K)
    • |<
    • <
    • 1
    • >
    • >|
feedback
 Top