Canine superficial pyoderma is mainly caused by Staphylococcus pseudintermedius and S. schleiferi on and/or in the epidermis dermis and the follicle. Due to the increased frequency of the isolation of drug-resistant bacteria from skin lesions, therapy for canine superficial pyoderma has become highly complicated. Accordingly, the Guideline Committee of the Japanese Society of Veterinary Dermatology has attempted to develop a guideline for the treatment of canine superficial pyoderma in Japanese veterinary practice. We referred to reviews and guidelines concerning canine skin infection which were mainly published in the US and European countries, and collected additional papers. Based on the findings, it is difficult to propose a guideline for Japanese practitioners at this moment, since evidence for the practice is quite limited. Through this research, we have gained an understanding of the current problems concerning therapies for canine superficial pyoderma. This article tries to present a clinical indication rather than a guideline based on previously published evidence. In addition, several issues facing current practice are also discussed.