Periodically repeating interdigital blood blisters were observed on the forelimbs of seven dogs: three Pekinese, three shih tzu, and one French bull dog. Average age of onset was 4.3 years old. Acute swelling along with lameness bilaterally or unilaterally appeared mainly at the 2nd and the 4th digital areas. The lesions healed within a few days, but reappeared repeatedly around one week to two months later. Anteflexion, and valgus of the forelimbs were prominent in all cases. Four cases with long-term observation were treated with carbazochrome sodium sulfonate hydrate as vascular reinforcement and went into remission. We speculate that vesicular rupture due to breed-related or age-related fragility associated structural distortion may play a role as a pathogenesis.

A golden retriever came to our hospital with papules and depigmentation around the paws. A diagnosis of epithelial tropic T-cell lymphoma was made based on histopathological examination of biopsy tissue. Treatment was initiated with retinoids, but the patient did not respond adequately. After switching to oclacitinib on day 204, the dog responded well and has continued to do well for more than one year after the start of this treatment without side effects. These results suggest that oclacitinib is effective and safe for the treatment of epitheliotropic T-cell lymphomas.

A 1-year-old female Golden Retriever was presented with swelling, crusting, and hemorrhage on the eyelids, lips, and nasal planum. Based on the clinical presentations and the histopathological findings, a diagnosis of sterile granulomatous dermatitis and lymphadenitis was made. The dog had been mated prior to the onset of the disease, and two of her litter developed the same disease at the age of 2 months.