Purpose: The aim of this study was to develop and evaluate application software for physicians to explain medication efficacy to patients with epilepsy. Methods: We developed application software for visualization of the attenuation of epileptic seizures on a three-dimensional (3-D) brain-surface shape model using magnitude texture mapping of abnormal neural activity. The magnitude of the abnormal neural activity was mathematically simulated by the Kim–Robinson model. The efficacy of the developed application software was confirmed by neurosurgeons (n = 7) via questionnaire. Results: The developed software was useful in explaining brain anatomy and function, epileptic seizure and medication adherence. Conclusions: The virtual reality application software developed in this study can be used to support patient awareness of the pathophysiology of epileptic seizures.

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