Erythrocytes show biconcaved disc configuration and passive bending deformation in microcirculation where er ythrocytes’ diameter is greater than the minimal diameter of microvasculature. Therefore, the whole cell deformability of circulating erythrocytes is a major determinant of fluent microcirculation. This deformability is reported to be impaired in patients with various systemic as well as cardiac diseases such as hypertension, diabetes and atrial fibrillation (AF) which is prevalent in this country where senescence is rapidly growing. This common arrhythmia is characteristic in that AF is age-dependent, progressive from paroxysmal to persistent and finally permanent form, and associated with ischemic cerebral thromboembolism, i.e., cardiogenic stroke is one of the major complications of AF. This devastating complication is likely to occur in AF patients with senescence, hypertension, diabetes, heart failure and previous embolic episodes. Many of these factors impair the erythrocyte deformability. In our multivariate analyses, AF is the greatest contributing factor of impaired erythrocyte deformability in outpatients visiting our hospital, suggesting that many factors impairing this deformability are accumulated in AF patients. Inflammatory endocardial surface and stagnant blood flow with hemoconcentration in fibrillating left atria establish the Virchow’s triad leading to thrombogenesis. However, direct relationship between the erythrocyte deformability and ischemic stroke in AF patients remains to be elucidated.
Background: Valvular regurgitation, a degenerative condition, increases in prevalence with age. Its impact on left ventricular (LV) function in the elderly remains unclear, however.
Objective: The purpose of this study was to characterize the relationship between LV function and valvular regurgitation in middle-aged and elderly.
Methods: Echocardiography was performed to assess LV systolic and diastolic function in 98 community-dwelling middle-aged and older adults. Mitral regurgitation (MR) and aortic regurgitation (AR) were qualitatively graded from absent or trivial to severe.
Results: The LV ejection fraction was significantly higher and the deceleration time at the mitral level during rapid filling significantly longer in the MR group than in the non-MR group. The ratio of early diastolic wave peak velocity to mitral annular early diastolic peak velocity was significantly greater in the AR group than in the non-AR group.
Conclusions: Both MR and AR may play an important role in change in LV systolic and diastolic function, even in cases of mild regurgitation, in middle-aged and elderly.
Objectives: This study aimed to determine which factors are associated with HbA1c levels among residents of Choshi City in Chiba, Japan.
Methods: We recruited 372 (age, 20−39 y) of 492 women who underwent a medical examination in Choshi City during 2015. Body composition, physical activity and serum adiponectin (Ad) values were measured.
Results: Among the participants, 155 (42％) women who had high HbA1c values (≥ 5.6％) weighed significantly more, had a significantly higher BMI and abdominal circumference, as well as serum LDL-Chol and TG values, and lower hemoglobin, HDL-Chol and Ad values than those with normal HbA1c. The women with high HbA1c had significantly more abnormal serum lipid and hemoglobin values that increased their risk for hyperlipidemia and anemia. High HbA1c levels were also associated with weight gain (＞10 kg compared with weight at the age of 20 years) and less alcohol consumption and skipping breakfast.
Conclusion: Weight gain and dietary habits are associated with HbA1c levels.