Journal of Clinical Physiology
Online ISSN : 2435-1695
Print ISSN : 0286-7052
Volume 49 , Issue 5
Journal of Clinical physiology
Showing 1-7 articles out of 7 articles from the selected issue
Review Article
Original Article
  • Yuji KAWASAKI, Tomoya HARADA, Kenichi TAKEDA, Akira YAMASAKI
    2019 Volume 49 Issue 5 Pages 169-173
    Published: December 01, 2019
    Released: March 06, 2020
    JOURNALS OPEN ACCESS

     Background: The prognostic role of N-terminal probrain natriuretic peptide (NT-proBNP) in patients with nursing- and healthcare-associated pneumonia remains to be determined.

     Objective: The purpose of this study was to investigate the relationship between serum NT-proBNP levels and short-term mortality in patients hospitalized for nursing- and healthcare-associated pneumonia.

     Methods: Performance status, A-DROP severity score for pneumonia, serum albumin levels, and serum NT-proBNP levels in 14 patients who died within 30 days of admission (30-day mortality group) and 101 surviving patients (sur vivor group) hospitalized for nursing- and healthcare-associated pneumonia were compared.

     Results: Serum albumin levels were lower and serum NT-proBNP levels higher in the 30-day mortality group than in the survivor group. Since serum NT-proBNP is a biomarker for heart failure, higher levels in the 30- day mortality group suggest that short-term mortality in patients hospitalized for nursing- and healthcareassociated pneumonia is associated with heart failure.

     Conclusion: Serum NT-proBNP might offer a useful prognostic marker for short-term mortality in patients hospitalized for nursing- and healthcare-associated pneumonia.

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  • Yuko NAKANISHI, Yoshio SUZUKI, Shinobu SAKURAI, Shimpei FUJITA, Mayumi ...
    2019 Volume 49 Issue 5 Pages 175-181
    Published: December 01, 2019
    Released: March 06, 2020
    JOURNALS OPEN ACCESS

     Background: Visceral fat area is most closely associated with the metabolic syndrome. Computed tomography (CT) and visceral fat meters are available as a means of measuring visceral fat area. CT scans are the gold standard for measuring visceral fat area, but since making the measurements is complicated and limited to measuring facilities, and there is X-ray exposure, they cannot be applied to large numbers of subjects as in medical checkups. The InBody 430 body composition analyzer uses direct segmental multifrequency bioelectrical impedance analysis (DSM-BIA); its design provides increased reproducibility and enables accurate, highly precise measurements. In addition, it may be possible to predict visceral fat area as a function of abdominal girth or of BMI and percent body fat. Moreover, visceral fat area is expected to be related to age and sex.

     Objectives: The purpose of this study was to estimate visceral fat area on the basis of percent body fat measured with the InBody analyzer, age, and anthropometric parameters.

     Methods: A total of 457 (119 male and 338 female) participants were recruited from two towns with quite different environments in Mie Prefecture. Their height, weight, abdominal girth, body composition, and visceral fat area were measured. Body composition was measured with an eightpolar bioelectric impedance analyzer, and visceral fat area was measured with a visceral fat meter. A prediction equation for estimating visceral fat area was obtained by multiple linear regression analysis. Visceral fat area was used as the dependent variable, and age and percent body fat × (abdominal girth)2 were used as the independent variables.

     Results: The visceral fat area, abdominal girth, and BMI values of the female participants were skewed in the smaller direction, and their age distribution showed a peak in the 20s-30s age range and in the 60s-70s age range. The percent body fat values of the female participants yielded an almost perfect bell-shaped curve. The distribution of the visceral fat area values of the male participants did not describe a clear bell-shaped curve, but the distributions of their percent body fat values and abdominal girth values yielded almost perfect bell-shaped curves. The ages of the male participants showed a peak in the 20s-30s range and in the 60s-70s range, and the distribution of their BMI values was skewed in the smaller direction. Of the parameters tested, percent body fat × (abdominal girth)2 showed the highest correlation coefficient with visceral fat area. Multiple regression gave the prediction equations to estimate visceral fat area using age and percent body fat × (abdominal girth)2; their coefficients of determination (R2) were 0.763 and 0.875 in male and female participants, respectively.

     Conclusion: Visceral fat area can be estimating using the formula obtained based on data that have been acquired with an existing body composition analyzer.

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  • Hideto MATSUDA, Kazuyoshi HASHIMOTO
    2019 Volume 49 Issue 5 Pages 183-190
    Published: December 01, 2019
    Released: March 06, 2020
    JOURNALS OPEN ACCESS

     Background: According to a national health and nutrition survey, the percentage of low-weight individuals with Body Mass Index (BMI) of 18.5 kg/m2 or lower is increasing amongst women in their 20s. Meanwhile, there is also an increasing risk of pregnant women of low body weight giving birth to low-weight or premature infants. Low birth-rate infants in turn carry a greater risk of adult-onset diseases later in life. In addition, cohort studies show that risk of death is lowest where BMI stands at 20.0–25.0kg/m2, while the risk of death increases greatly at a BMI of less than 20.0 kg/m2.

     Objectives: Taking a BMI of 20.0 kg/m2 as a cutoff, we examined trends in blood sugar and plasma insulin after eating.

     Methods: Subjects in a group of healthy young women were given rice balls to eat, subsequent to which changes in their blood sugar and plasma insulin where monitored. The low-weight group that had a BMI of less than 20.0 kg/m2 was compared to a group with a BMI of greater than 20.0 kg/m2.

     Results: Though the blood sugar of the low-weight group was significantly higher both 30 minutes and 60 minutes after eating than the higher-weight group, there was no significant difference in plasma insulin levels between the two groups.

     Conclusion: The study pointed to a potential risk of lifestyle related disease in low-weight young women, due to the fact that their blood sugar levels were significantly higher than the higher-weight group one hour after consuming the rice balls.

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  • Hiroki TABATA, Hyeon-ki KIM, Masayuki KONISHI, Naoya ENDO, Shizuo SAKA ...
    2019 Volume 49 Issue 5 Pages 191-200
    Published: December 01, 2019
    Released: March 06, 2020
    JOURNALS OPEN ACCESS

     Objectives: This study aimed to investigate the substrate metabolism response to moderateand high-intensity equicaloric exercises in endurance-trained men.

     Methods: Ten male endurance-trained runners (mean ± standard error: age, 22 ± 1 years; body mass index, 19.3 ± 0.7 kg/m2; ⩒O2max, 64.1 ± 2.1 mL/kg/min) performed a graded exercise test on a treadmill to determine the exercise intensity at which elicits maximal fat oxidation (Fatmax) and subsequently completed two equicaloric exercises (53 min at Fatmax and 30 min at 65%⩒O2max). Substrate oxidation rates during exercise and 2-h post-exercise recovery period were determined using indirect calorimetry. Blood samples were collected before exercise; immediately post-exercise; and at 30 min, 1 h, and 2 h post-exercise to determine plasma noradrenaline, serum growth hormone (GH), and free fatty acid (FFA) concentrations.

     Results: Mean Fatmax was observed at 37.3 ± 4.6 %⩒O2max. Fat oxidation volume during exercise was significantly higher in the Fatmax trial than in the 65%⩒O2max trial (15.2 ± 1.5 g vs 8.5 ± 0.7 g, P < 0.01). No significant difference in fat oxidation occurred in the post-exercise recovery period. Serum GH and plasma noradrenaline concentrations were higher at 65%⩒O2max than at Fatmax immediately post-exercise (P < 0.05). However, there was no difference in serum FFA levels between exercise intensities.

     Conclusions: Exercise at Fatmax oxidized more fat than exercise at 65%⩒O2max when matched for energy expenditure during exercise in endurance-trained men.

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