This review sheds light on the evolving trends in Minimal Intervention (MI) dentistry, particularly in direct resin composite restorations. The expansion of resin composite restorations' applications has led to the development of novel adhesive techniques for enhanced bond durability and innovative restoration methods utilizing digital technology. This paper elaborates on smear layer deproteinizing pretreatment (SLDP), which has been found to significantly improve dentin bond durability. Furthermore, we explore the digitally-guided direct resin composite restoration, a method that combines the clinical efficacy of analogue and digital restoration methods. This innovative technique standardizes treatment procedures, reduces reliance on the dentist's skill, and improves treatment outcomes. The review also examines the emerging non-destructive inspection technique, terahertz pulsed imaging, which has revolutionized the internal visualization of the adhesive interface between tooth substrates and biomaterials. The paper underscores the crucial role of digital workflows and the development of new adhesive technique, resin composite materials, and non-destructive testing methods in shaping the future of restorative treatments, collectively termed Advanced MI Dentistry. We call for further basic and clinical studies to continue advancing this vital field.
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