Journal of Reproduction and Development
3,892 registered articles
(updated on May 20, 2022)
Online ISSN : 1348-4400
Print ISSN : 0916-8818
ISSN-L : 0916-8818
JOURNAL PEER REVIEWED OPEN ACCESS ADVANCE PUBLICATION
DOAJ Scopus Pubmed
Featured article
Volume 68 (2022) Issue 2 Pages 110-117
Epithelial-mesenchymal transition and bi- and multi-nucleated trophoblast cell formation in ovine conceptuses during the peri-implantation period Read more
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Cover Story:
To understand the cellular processes associated with non-invasive mode of conceptus implantation to the maternal endometrium, Yamada
et al. observed the conceptus implantation process via adhesion of trophoblast cells to the uterine epithelium (Yamada et al., Epithelial-mesenchymal transition and bi- and multi-nucleated trophoblast cell formation in ovine conceptuses during the peri-implantation period, pp. 110–117). Similar to human syncytiotrophoblast, ruminant trophoblasts form bi- and multi-nucleated trophoblast cells. Using pregnancy associated glycoproteins (PAGs) specific antibody, bi- and multi-nucleated trophoblast cells in cross sections of day 21 ovine uteri (day 0 = day of estrus), including elongated conceptuses, were observed, and it was found that bi- and multi-nucleated trophoblast cells existed on the uterine epithelium or next to the uterine stroma. These results suggest that the formation of bi- and multi-nucleated trophoblast cells facilitates the placental formation in ruminants.

Volume 68 (2022) Issue 1 Pages 53-61
Effects of reduced glutathione supplementation in semen freezing extender on frozen-thawed bull semen and in vitro fertilization Read more
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Cover Story:
Ogata et al. investigated the effects of reduced glutathione (GSH) supplementation in a freezing extender on frozen-thawed semen quality and subsequent in vitro fertilization (IVF) results (Ogata et al. pp. 53–61). GSH supplementation did not affect sperm viability or acrosome integrity (left panel, FITC-PNA staining) in any of the bulls, although few bulls displayed increased DNA damage (right panel, TUNEL staining). However, pronucleus formation and embryonic development after IVF improved in those bulls. These results suggest that supplementing the freezing extender with GSH may improve in vitro embryo production from frozen semen.

Volume 67 (2021) Issue 6 Pages 386-391
Steroidal but not embryonic regulation of mucin 1 expression in bovine endometrium Read more
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Cover Story:
The endometrial surface is required to reject attachment of exogenous undesirable substances such as pathogens, while occasionally shifting properties to allow physical interaction with an embryo to support a successful pregnancy. Kubota et al. reported that MUC1, a potent inhibitor of cellular contact via its large extracellular glycoprotein domain, localizes to the apical surface of bovine endometrium (upper panel, green staining). This MUC1 barrier can be removed in response to steroid signaling at receptive phase and during pregnancy (lower panel), as revealed by immunohistochemistry (p. 386–391). Red signal (pseudo-color) represents DAPI-stained nuclei. Interestingly, MUC1 expression is elevated in the endometrium of cows with a long postpartum interval, which is a known risk for reducing female fertility. Thus, this observation is consistent with the proposed anti-attachment role of MUC1. These results suggest that MUC1 regulation plays a role in endometrial homeostasis and embryo implantation, and its negative correlation with fertility may be used as a diagnostic of reproductive efficiency.

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