There have been several reports on the usefulness of OK-432 sclerotherapy for ranula; however, reports on alternative drugs remain limited, despite the need for effective agents with fewer side effects.
This study evaluated the usefulness and safety of 50% hypertonic glucose solution (HGS) as an alternative drug to OK-432. Of the 42 patients with ranula who were examined at our department during 13 years, 10 treated by sclerotherapy (7 with 50% HGS and 3 with OK-432) were selected, and their age, sex, disease type, treatment, presence of adverse reactions, and clinical course were evaluated. The responses were rated as (1) “disappearance,” (2) “reduction in size,” or (3) “no response.” The responses were rated as “disappearance” in 4, “reduction in size” in 2, and “no response” in 1 of the 7 patients treated with 50% HGS, and as “disappearance” in all 3 patients treated with OK-432 by two rounds of sclerotherapy. In addition, although OK-432 was more consistently effective than 50% HGS, 50% HGS had few adverse reactions. As a comprehensive evaluation, the outcome was clearly more favorable with OK-432 than with 50% HGS, but 50% HGS is considered to be a useful alternative for patients who cannot tolerate OK-432.
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