Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics

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24th JSSX Annual meeting

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Poster Presentations

ASSESSMENT OF PHRMACOKINETICS / PHARMACODYNAMICS OF NK012, A MICELLE-FORMING PRODRUG OF SN-38, AND CPT-11 AGAINST HUMAN BREAST CANCER XENOGRAFT

Shinichi Matsumoto, Eiji Ichimura, Noriko Watanabe, Takeshi Onda, Hito ...

Session ID: 2-P-07
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.251.0

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NEGATIVE INVOLVEMENT OF CYTOSKELETAL REORGANIZATION IN REPEATED EXPRESSION OF TRANSGENES FROM SILENCED VECTORS

Naomi Takiguchi

Session ID: 2-P-08
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.252.0

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NOVEL NANOCRYSTAL SOLID DISPERSION OF TRANILAST FOR INHALATION THERAPY

BIOMARKER-BASED PHARMACODYNAMIC AND PHARMACOKINETIC CHARACTERIZATIONS

Yosuke Aoki, Takuya Matsui, Yohei Kawabata, Kiyosi Yamamoto, Hideyuki ...

Session ID: 2-P-09
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.253.0

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CELL SURFACE MODIFICATION OF MESENCHYMAL STEM CELL MAMBRANE BY LIPID DERIVATIVE

Atsushi Muro, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, M ...

Session ID: 2-P-10
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.254.0

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EFFECT OF YOKUKANSAN ON THE CYTOCHROME P450

Mariko Yoshizawa, Saori Ichisawa, Nobutomo Ikarashi, Kiyomi Ito, Watar ...

Session ID: 2-P-11
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.255.0

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MECHANISM FOR DECREASED DIGOXIN CONCENTRATION BY FEXOFENADINE IN HEMODIALYSIS PATIENTS

Daisuke Shima, Masayuki Tsujimoto, Shima Hiraoka, Ayaka Miyoshi, Tetsu ...

Session ID: 2-P-12
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.256.0

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VALIDATION OF CYTOCHROME P450 TIME-DEPENDENT INHIBITION ASSAYS

Mikako Torii, Hiroyuki Yokoyama, Hiroshi Iwata

Session ID: 2-P-13
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.257.0

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IN VITRO ESTIMATION OF P-GLYCOPROTEIN-MEDIATED INTERACTION OF DRUGS WITH CREMOPHOR EL BY USING DISSOLUTION/PERMEATION SYSTEM

Makoto Kataoka, Tomonori Yokoyama, Yoshie Masaoka, Shinji Sakuma, Shin ...

Session ID: 2-P-14
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.258.0

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LC-MS/MS METHOD FOR QUANTITATION OF ALPRAZOLAM, A TYIPICAL CYP3A SUBSTRATE, IN PLASMA AND URINE ON IN VIVO DRUG-DRUG INTERACTION STUDY IN CYNOMOLGUS MONKEY

Takahiro Yoshikawa, Takatoshi Nakamura, Masahiro Utoh, Koichiro Fukuza ...

Session ID: 2-P-15
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.259.0

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EVALUATION OF TIME-DEPENDENT INHIBITION OF DRUG METABOLIZING ENZYMES IN RATS

Toshihiko Hirano

Session ID: 2-P-16
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.260.0

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COMPARISON OF EFFECT OF DIETS ON METABOLITE PROFILES IN MOUSE URINE USING 1H-NMR SPECTROSCOPY

Hanaka Sako, kazumi Sugihara, Miyuki Arai, Seigo Sanoh, Shigeyuki Kita ...

Session ID: 2-P-17
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.261.0

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STRAIN AND SEX DIFFERENCES OF ALDEHYDE OXIDASE IN MOUSE

Takahiro Kishino, Kazumi Sugihara, Seigo Sanoh, Yoshitaka Tayama, Shig ...

Session ID: 2-P-18
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.262.0

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DEVELOPMENT OF A SIMPLE UDP-GLUCURONOSYLTRANSFERASE ASSAY FOR UGT1A1, UGT1A4, UGT1A6, AND UGT2B7

Takuya Teragaki, Yasuharu Nakanishi, Kanako Yajima, Kazuhide Iwasaki, ...

Session ID: 2-P-19
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.263.0

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ENZYME-ASSISTED SYNTHESIS OF GLUCURONIDES USING UDP-GLUCURONOSYLTRANSFERASES EXPRESSED IN YEAST

Shinichi Ikushiro, Shinsuke Uchihashi, Yuuka Masuyama, Kaori Yasuda, S ...

Session ID: 2-P-20
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.264.0

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DEVELOPMENTAL CHANGES OF ALDEHYDE OXIDASE ACTIVITY IN THREE MONOZYGOTIC TWINS.

Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Shigeru Ohta

Session ID: 2-P-21
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.265.0

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INVOLVEMENT OF NFKB IN LPS INDUCED DOWNREGULATION OF NUCLEAR RECEPTOR MEDIATED HEPATIC CYP FAMILY GENE EXPRESSION

Nozomu Moriya, Hiromi Kataoka, Hideki Fujino, Jun-ichi Nishikawa, Fumi ...

Session ID: 2-P-22
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.266.0

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EFFECTS OF CYP2C8 INHIBITORS ON REPAGLINIDE METABOLISM

Tomoko Inoue, Michiaki Matsuda, Jin Shimakura, Kiyoshi Natsui, Takanor ...

Session ID: 2-P-23
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.267.0

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EFFECT OF HYDROCOTARNINE ON THE CYP AND UGT EXPRESSION IN THE MOUSE LIVER

Nobutomo Ikarashi, Satoshi Suto, Asano Hotta, Kiyomi Ito, Wataru Ochia ...

Session ID: 2-P-24
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.268.0

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ENHANCEMENT OF BETA-NAPHTHOFLAVONE-INDUCED CYP1A1 MRNA EXPRESSION BY ANDROGRAPHOLIDE IS MODULATED BY ALTEREDINTRACELLULAR GSH CONTENT

Sachiko Kondo, Tsutomu Sakuma, Nobuo Nemoto

Session ID: 2-P-25
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.269.0

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APPLICATION OF THE MULTIPLE REGRESSION APPROACH TO PREDICT THE CONTRIBUTION OF CYTOCHROME P450 (CYP) ISOZYMES IN THE DISCOVERY STAGE

Yasuhisa Fukunaga, Hidetsugu Murai, Shigeyuki Terashita, Toshio Teramu ...

Session ID: 2-P-26
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.270.0

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DEVELOPMENT OF A NOVEL CYP-EXPRESSING CELL SYSTEM FOR HUMAN METABOLISM RESEARCH

Miki Fujishima

Session ID: 2-P-27
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.271.0

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POSSIBILITY OF NEGATIVE REGULATORY REGION WITHIN Cyp2b10 PROMOTER

Sawako Shindo, Satoshi Numazawa, Takemi Yoshida

Session ID: 2-P-28
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.272.0

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FUNCTIONL CHARACTERIZATION OF CYP3A4.16 AND CYP3A4.18

CATALYTIC ACTIVITES TOWARD MIDAZOLAM,CARBAMAZEPINE,ATORVASTATIN AND PACLITAXEL

Yoshiyuki Fujimura, Keiko Maekawa, Su-Ryang Kim, Jun-ichi Sawada, Yosh ...

Session ID: 2-P-29
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.273.0

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SPECIES DIFFERENCE IN HEPATIC AND INTESTINAL METABOLIC ACTIVITY OF P450 SUBSTRATES

Haruka Nishimuta, Kimihiko Sato, Yasuyuki Mizuki, Setsuko Komuro

Session ID: 2-P-30
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.274.0

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Metabolism of ibuprofen in chimeric mice with humanized liver

Aya Horiguchi, Seigo Sanoh, Kazumi Sugihara, Tae Inoue, Chise Tateno, ...

Session ID: 2-P-31
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.275.0

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EVALUATION OF A DRUG'S METABOLIC STABILITY AND STRUCTURE ANALYSIS OF ITS METABOLITES BY MULTIPLE REACTION MONITORING

Tomonori Takami, Yukiko Nishida, Shohei Shioyama, Rieko Goto

Session ID: 2-P-32
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.276.0

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MRM3 FOR QUANTIFICATION WITH ULTRA HIGH SPECIFICITY

Shigeru Yamada, Chie Inagaki

Session ID: 2-P-33
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.277.0

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A NEW APPROACH FOR TARGETED AND NON-TARGETED SCREENING OF XENOBIOTIC AND ENDOGENOUS METABOLITES

Kaoru Karasawa

Session ID: 2-P-34
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.278.0

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ANALYSIS OF IN-VIVO SAMPLES FOR METABOLITE IDENTIFICATION WITH A MODIFIED Q-TOF MASS SPECTROMETER WITH ENHANCED DYNAMIC RANGE AND SPECTRAL RESOLUTION

Motoji Oshikata, Yasuhiro Yamada, Jose Castro-Perez, Yukari Haramaki, ...

Session ID: 2-P-35
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.279.0

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PLASMA AND URINE PROFILING OF INTACT ISOFLAVONE METABOLITES

Kaori Hosoda, Takashi Furuta, Kazuo Ishii

Session ID: 2-P-36
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.280.0

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BRIDGING IMMUNOGENICITY ASSAY USING ELECTRO-CHEMILUMINESCENT DETECTION

Tomoyoshi Koshiyama, Kazuhiko Sonehara, Hisashi Iwatou, Harumi Sakai, ...

Session ID: 2-P-37
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.281.0

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APPLICABILITY OF ATMOSPHERIC PRESSURE PHOTOIONIZATION AND ATMOSPHERIC PRESSURE CHEMICAL IONIZATION TO MASS SPECTROMETRIC DETECTION OF DRUGS WITH MODERATE TO HIGH HYDROPHILICITY

Makoto Niwa, Takashi Kawashiro

Session ID: 2-P-38
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.282.0

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WHAT ROLE CAN ACCELERATOR MASS SPECTOMETRY PLAY IN HUMAN PHASE I?

Tsuyoshi Masatsugu, Yoshimi Hamabe, Takao Matsui

Session ID: 2-P-39
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.283.0

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BBB HYPERPERMEABILITY TO SODIUM FLUORESCEIN IN HIGH FAT DIET-INDUCED OBESE MICE WITH IMPAIRED GLUCOSE TOLERANCE

A COMPARISON STUDY USING ICR, C57BL/6J, AND DB/DB MICE

Takashi Obara, Shinya Dohgu, Fuyuko Takata, Tsuyoshi Nishioku, Atsushi ...

Session ID: 2-P-40
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.284.0

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HIGH SENSITIVE ANALYSIS OF METABOLIC PROFILE OF RADIOLABELED COMPOUND USING TOPCOUNT COPLED TO HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

Yosuke Kaneko, Hiroyuki Sasabe, Toru Ofuchi, Toshiyuki Tadenuma, Eiji ...

Session ID: 2-P-41
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.285.0

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A PLANT-DERIVED PDG INHIBITS CFTR CHLORIDE CHANNELS: POTENTIAL THERAPY FOR SECRETORY DIARRHEA

Chatchai Muanprasat, Nisa Wongsamitkul, Varanuj Chatsudthipong

Session ID: 2-P-42
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.286.0

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PROMISING TOXICOLOGICAL BIOMARKERS FOR DIAGNOSIS OF LIVER INJURY TYPES

BILE ACID METABOLIC PROFILES AS SCREENING TOOL IN DRUG DEVELOPMENT

Noriko Masubuchi, Takayoshi Nishiya, Masako Imaoka, Kiyoko Mizumaki, S ...

Session ID: 2-P-43
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.287.0

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ALKOXYALKYL ESTERS OF ASIATIC ACID AS ASIATICOSIDE MIMETICS

Hee-Doo Kim, Eun Hee Park

Session ID: 2-P-44
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.288.0

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COMPARISON OF TRANSPORTER-MEDIATED UPTAKE, EFFLUX AND METABOLIC FUNCTION IN FRESH AND CRYOPRESERVED HEPATOCYTES, IN SUSPENSION AND PRIMARY CULTURE

Jasminder Sahi, Erica Deibert, Manda Edwards, Joy Mitchell, Patricia P ...

Session ID: 2-P-45
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.289.0

CONFERENCE PROCEEDINGS FREE ACCESS

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EVALUATION OF FOOD-DRUG INTERACTIONS BY IN VITRO INHIBITION ASSAY OF P450-DEPENDENT DRUG METABOLISM

Yuki Honda, Shinichi Ikushiro, Kaori Yasuda, Toshiyuki Sakaki, Toshio ...

Session ID: 2-P-46
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.290.0

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CHARACTERIZATION OF MICRO-SPACE CELL CULTURE PLATES USING HUMAN HEPATOCYTES

Yoko Ejiri, Masaya Hosoda, Motohiro Fukuda, Kazuaki Nakamura, Norie Mu ...

Session ID: 2-P-47
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.291.0

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OPTIMIZATION OF D/P SYSTEM FOR THE USE OF MDCK II CELL MONOLAYER TO ESTIMATE HUMAN ORAL DRUG ABSORPTION.

Tomotaka Shingaki, Taiji Shimoda, Shoko Takeyama, Naoko Futamatsu, Jyo ...

Session ID: 2-P-48
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.292.0

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DEVELOPMENT OF CATEGORY APPROACH MODEL TO PREDICT CHEMICAL HEMATOTOXICITY

HuiQi Zhang

Session ID: 2-P-49
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.293.0

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SEARCH OF FACTORS AFFECTING PHARMACOKINETIC BEHAVIOR INDUCED BY MULTI-DRUG REGIMENT OF PSYCHOTROPIC DRUGS

-ROLE OF CYTOCHROME P-450 AND MATE1-

Teiichi Masuyama

Session ID: 2-P-50
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.294.0

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INTERACTION OF PERFLUOROOCTANE SULFONATE WITH HUMAN HEPATIC CYTOCHROME P450 ENZYMES

Ryoko Nakanishi, Nobumitsu Hanioka, Keita Saito, Hiroyuki Kataoka, Shi ...

Session ID: 2-P-51
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.295.0

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MECHANISMS OF PROTECTION BY ETHYNYLESTRADIOL AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY IN MICE

Yasuhiro Masubuchi, Yoshiki Kobayashi, Yasuko Watanabe

Session ID: 2-P-52
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.296.0

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MECHANISMS OF AMELIORATION FOR CISPLATIN-INDUCED NEPHROTOXICITY BY DIURETIC DRUGS AND METHIMAZOLE IN RATS

EFFECTS ON PHARMACOKINETICS AND RENAL EXPRESSION OF PROTEINS AND MRNA

Kazuhiko Hanada, Kunihito Asano, Masanori Watabnabe, Junichi Mochizuki ...

Session ID: 2-P-53
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.297.0

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SUPPLEMENTARY REACTION TO DRUG METABOLISM IN THE MULTIPLE HISTAMINE RECEPTOR GENE KNOCKOUT MICE

Eiichi Sakurai, Eiko Sakurai, Yukari Ueda, Kazuhiko Yanai

Session ID: 2-P-54
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.298.0

CONFERENCE PROCEEDINGS FREE ACCESS

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DETERMINATION OF IBUPROFEN DRUG METABOLITES AND RELATED BIOMARKERS IN URINE BY THE USE OF MULTIVARIANT ANALYSIS

Masahiro Maeda, Yoshifumi Kogure, Yoshihisa Ishii

Session ID: 2-P-55
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.299.0

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HIGH SENSITIVITY MEASUREMENT BY NEW TECHNIQUES ON LIQUID SCINTILLATION COUNTER

Norio Nogawa

Session ID: 2-P-56
Published: 2009
Released on J-STAGE: November 26, 2009

DOIhttps://doi.org/10.14896/jssxmeeting.24.0.300.0

CONFERENCE PROCEEDINGS FREE ACCESS

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