Establishment of an in vitro cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids

公開日: 2023/01/05 | 48 巻 1 号 p. 47-56

Toshihisa Koga, Kenji Takeuchi, Ken Umehara

Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats

公開日: 2023/01/05 | 48 巻 1 号 p. 1-14

Norimichi Hattori, Hideaki Yokoyama, Asuka Takumi, Sayaka Kawaguchi, Koki Yamaguchi, Taishi Shimazaki, Yusuke Shibui, Kosuke Saito, Yoshiro Saito

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality

公開日: 2023/01/05 | 48 巻 1 号 p. 37-45

Yoko Mori, Toshiko Tanaka-Kagawa, Maiko Tahara, Tsuyoshi Kawakami, Akira Aoki, Yoshinori Okamoto, Takashi Isobe, Susumu Ohkawara, Nobumitsu Hanioka, Kenichi Azuma, Shinobu Sakai, Hideto Jinno

Methylthioacetic acid, a derivative of aroma compounds from Cucumis melo var. conomon dose-dependently triggers differentiation and apoptosis of RCM-1 human colorectal cancer cells

公開日: 2023/01/05 | 48 巻 1 号 p. 25-35

Miyu Kamimura, Azusa Sasaki, Yui Otani, Yasushi Nakamura, Takako Nakamura, Kouji Kuramochi, Toshio Imai, Nakao Kubo, Shigehisa Okamoto

Rapid derivatization of phosphorus-containing amino acid herbicides in plasma and urine using microwave heating

公開日: 2023/01/05 | 48 巻 1 号 p. 15-24

Hiroyuki Mohri, Kazuko Mohri, Akinaga Gohda, Yuji Ishii