The Journal of Toxicological Sciences

2022 年 47 巻 1 号

A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes Chika Yamamoto, Akinori Takemura, Sanae Ishii, Atsushi Doi, Isao Saito, Hideki Yamada, Yoko Sakai, Tamihide Matsunaga, Kousei Ito
Acyl-CoA:diacylglycerol acyltransferase 1 inhibition in the small intestine increases plasma transaminase activity via the activation of protein kinase C pathway Hideaki Yokoyama, Taku Masuyama, Yuki Tanaka, Iori Tsubakihara, Kazuma Kondo, Kouichi Yoshinari
HepG2-NIAS cells, a new subline of HepG2 cells that can enhance not only CYP3A4 activity but also expression of drug transporters and form bile canaliculus-like networks by the oxygenation culture via a collagen vitrigel membrane Toshiaki Takezawa, Miaki Uzu
Development challenges for carcinogenicity risk assessments of topical drugs Brett D Hollingshead, Nasir Khan, Maik Schuler, Zaher Radi

最新号のすべての記事を見る

月間アクセス数ランキング 2021年12月

1

Effects of excessive sodium chloride loading in the spontaneously diabetic torii (SDT) fatty rats, a preclinical model of type 2 diabetes mellitus

公開日: 2021/12/01 | 46 巻 12 号 p. 589-599

Soon Hui Teoh, Katsuhiro Miyajima, Yuichi Shinozaki, Masami Shinohara, Keiichi Ohata, François Briand, Rika Morimoto, Yuka Nakamura, Kinuko Uno, Noriko Kemuriyama, Dai Nakae, Takeshi Ohta, Tatsuya Maekawa
2

Association between in vitro nuclear receptor-activating profiles of chemical compounds and their in vivo hepatotoxicity in rats

公開日: 2021/12/01 | 46 巻 12 号 p. 569-587

Susumu Kodama, Nao Yoshii, Akihiro Ota, Jun-ichi Takeshita, Kouichi Yoshinari, Atsushi Ono
3

Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver

公開日: 2021/12/01 | 46 巻 12 号 p. 601-609

Kohei Matsunaga, Jun Abe, Keiko Ogata, Satoki Fukunaga, Sachiko Kitamoto
4

A rapid screening assay for L452R and T478K spike mutations in SARS-CoV-2 Delta variant using high-resolution melting analysis

公開日: 2021/10/01 | 46 巻 10 号 p. 471-476

Akira Aoki, Hirokazu Adachi, Yoko Mori, Miyabi Ito, Katsuhiko Sato, Kenji Okuda, Toru Sakakibara, Yoshinori Okamoto, Hideto Jinno
5

Pharmacokinetics of primary metabolites 5-hydroxythalidomide and 5′-hydroxythalidomide formed after oral administration of thalidomide in the rabbit, a thalidomide-sensitive species

公開日: 2021/12/01 | 46 巻 12 号 p. 553-560

Makiko Kuwagata, Takuro Hasegawa, Hiromasa Takashima, Makiko Shimizu, Satoshi Kitajima, Hiroshi Yamazaki

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