This investigation was made for effects of smoking on BMI, body fat ratio. [Subjects and methods] : the person who have experience of smoking 20 cigarettes or more per day for 2 years were selected. The serum leptin levels were measured by RIA kit. [Result] : There was no significance between smoking group (n=96) and non-smoking group (n=395) in BMI. However body fat ratio of smoking groups was decreased significantly in non-smoking group (p<0.05) . The parameters affecting the body fat ratio had examined by means of multi-regression analysis were shown the highest correlations with the Leptin. In the smoking group, however correlation was decreased. Leptin/fat ratio also decreased significantly in smoking group. This suggests that smoking may prohibits the production of leptin and in the smoking group, in spite of having similar BMI against of the non-smoking group suggests the increased susceptibility to leptin.

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