To assess the structure of cancellous tissue in the vertebral bone marrow, we analyzed the restricted diffusion using diffusion kurtosis. On a 1.5T MRI, single-shot diffusion echo planar imaging was used with b values of 0, 20, 120, 500, 1200 and 2200 s/mm
2, and a sensitivity encoding technique. Apparent diffusion kurtosis (
Kapp) and apparent diffusion coefficient (
Dapp) were calculated from diffusion kurtosis analysis based on non-Gaussian diffusion theory.
Kapp and
Dapp were determined in the lumbar vertebral body of seven normal subjects, and then compared with the bone mineral density (BMD) obtained with dual-energy X-ray absorptiometry. Moreover, fat fraction (FF) of the bone marrow was measured with spectral presaturation with inversion recovery in the same subject. A strong positive correlation was found between
Kapp and BMD (R
2 = 0.63,
P = 0.034) , and FF (R
2 = 0.72,
P = 0.015) . However, there was no significant correlation between
Dapp and BMD, and FF. These results indicating the greater utility of the
Kapp than that of the
Dapp. Water-restricted diffusion analysis with diffusion kurtosis makes it possible to obtain more detailed information on the structure of cancellous tissue and the bone metabolism.
View full abstract