Journal of The Society of Japanese Women Scientists
Online ISSN : 2186-3776
Print ISSN : 1349-4449
ISSN-L : 1349-4449
Volume 13, Issue 1
Displaying 1-3 of 3 articles from this issue
Review
  • Miyuki Sato
    Article type: Review
    2013 Volume 13 Issue 1 Pages 9-13
    Published: 2013
    Released on J-STAGE: May 27, 2013
    JOURNAL FREE ACCESS
    Fertilization triggers the transition from oocytes to fertilized eggs (zygotes). Using Caenorhabditis elegans as a model system, we have shown that membrane trafficking such as exocytosis, endocytosis and autophagy is dynamically regulated during this period to promote remodeling of cellular and extracellular components. Especially, autophagy is induced shortly after fertilization and eliminates sperm-derived paternal mitochondria and their genome selectively in the early embryos. The mitochondrial genome is maternally inherited in many eukaryotes but the mechanism has remained unknown. Our results suggest that the autophagic degradation of paternal mitochondria is the mechanism required for maternal inheritance of mitochondrial genome.
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  • Nanako Kawaguchi
    Article type: Review
    2013 Volume 13 Issue 1 Pages 14-22
    Published: 2013
    Released on J-STAGE: May 27, 2013
    JOURNAL FREE ACCESS
    Initially bone marrow stem cells were used for cardiomyocyte regeneration. Then, the concept of cardiac stem cells (CSCs) in adult hearts was proposed. Studies have proved the existence of stem cells in the heart. These somatic stem cells have been studied for use in cardiac regeneration. Recently, induced pluripotent stem cells (iPSCs) were invented, and methodologies have been developed to induce stable cardiomyocyte differentiation and purification of mature cardiomyocytes. A direct reprogramming method has also been invented using cardiac fibroblasts into cardiomyocytes. Here, I address cardiomyocyte regeneration using somatic stem cells and iPSCs. Furthermore, I describe the potential of CSCs in regenerative biology and regenerative medicine from our studies.
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SJWS Special Project Lecture
  • Kazuko Uno
    Article type: SJWS Special Project Lecture
    2013 Volume 13 Issue 1 Pages 23-29
    Published: 2013
    Released on J-STAGE: May 27, 2013
    JOURNAL FREE ACCESS
    The March 11th 2011 radiation incident in Fukushima, Japan, led to severe problems of low-dose radiation contamination of the surrounding environs. This has been causing panic and confusion among the population. Additionally, evaluating to what degree low-dose radiation will affect humans is a controversial issue among scientists. To help alleviate the confusion and panic, the Japan Society for the Promotion of Science dispatched a team of scientists (of which I am a member) to measure radiation contamination in Fukushima prefecture and explained the effects of low-dose radiation. Through these efforts we have provided the following information to residents: 1) Genes are not directly affected by low-dose radiation, but indirectly affected by radicals. 2) Radiation-damaged cells take more than 20 to 30 years to develop into clinical cancer. 3) Our immunological surveillance system is important to disease prevention and impairment of this system due to psychological stress, can result in an increased risk of cancer development. 4) Risks from exposure to radiation could be overcome or greatly reduced through lifestyle changes that include eating more anti-oxidant rich foods. The residents in Fukushima appreciate the efforts made by the Japan Society for the Promotion of Science. The scientists have benefitted as well since we have an opportunity to improve our ability to assess and communicate risk in disaster areas. Additionally, it is important to establish a more collaborative network with scientists from many fields, in order to help alleviate the critical situation that has resulted from the Fukushima radiation incident.
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