The Tohoku Journal of Experimental Medicine

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Hsa-miR-485-3p can be Involved in the Progression of Diabetic Retinopathy by Targeting IL1RN

Sha Zheng, Mei Long, Yi Chen

Article type: Regular Contribution
Article ID: 2025.J055
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J055

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A High Ratio of D-1 Dimer to Brain Natriuretic Peptide and Large Right-to-Left Shunt by Contrast-Enhanced Transthoracic Echocardiography as Risk Factors for Cryptogenic Stroke in Patent Foramen Ovale

Fuwang Zhang, Wenfang Cui

Article type: Regular Contribution
Article ID: 2025.J056
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J056

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Effectiveness of Remote Symptom 1 Monitoring and Progressive Muscle Relaxation in Enhancing Well-Being and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy

Yong Jiang, Jing-Ping Yang, Qin Liu

Article type: Regular Contribution
Article ID: 2025.J057
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J057

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Clinical Significance and Biological Role of lncRNA linc00893 in Diabetic Retinopathy

Jingdi Zhang, Wenhan Lu, Dan Xu

Article type: Regular Contribution
Article ID: 2025.J058
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J058

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Clinical Significance and Functional Analysis of miR-487b-3p in Ovarian Cancer

Shixi Zhang, Jing Chen, Qian Gao, Yan Li, Chao Wang

Article type: Regular Contribution
Article ID: 2025.J059
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J059

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Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: A Retrospective Analysis of 106 Cases

Jianbo Li, Min Fang

Article type: Regular Contribution
Article ID: 2025.J052
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J052

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Clinical Value and Molecular Mechanism of MiR-411-5p in Coronary Atherosclerosis

Chang Liu, Yingying Wang, Menghao Sun, Tingqi Shi

Article type: Regular Contribution
Article ID: 2025.J053
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J053

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Development and Performance Evaluation of a Novel Mobile X-ray System for Use in Disaster Situations

Masaki Fujisawa, Yohei Inaba, Toshiki Kato, Masatoshi Suzuki, Koichi C ...

Article type: Review
Article ID: 2025.J054
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J054

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Oxymatrine Inhibits PKM2-Mediated Glycolysis and Enhances Cisplatin Sensitivity in Bladder Cancer

Hui Zhang, Jun Li

Article type: Regular Contribution
Article ID: 2025.J049
Published: 2025
Advance online publication: May 08, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J049

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Calcitriol Prevents Isoproterenol-Induced Myocardial Fibrosis by Regulating the TGF-β1/SMAD Sensor via Binding to the Nuclear Vitamin D Receptor

Jinhua Wang, Qingling Wang, Chunyan Huang, Bin Zhang, Qihu Wang, Tingb ...

Article type: Regular Contribution
Article ID: 2025.J050
Published: 2025
Advance online publication: May 08, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J050

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Hypokalemia-Induced Rhabdomyolysis with Coexisting Hypomagnesemia A Case Report

Kiyoshi Migita, Kazufumi Yamasaki, Yoshiharu Takenaka, Ryosuke Shimani ...

Article type: Case
Article ID: 2025.J051
Published: 2025
Advance online publication: May 08, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J051

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Anti-MDA5 Dermatomyositis Induced by COVID-19 Following Recombinant　SARS-CoV-2 Vaccination: A Case Report

Yuya Sumichika, Shuzo Sato, Mai Endo, Kenji Saito, Shuhei Yoshida, Har ...

Article type: Case
Article ID: 2025.J047
Published: 2025
Advance online publication: May 01, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J047

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Factors Related to Recruitment and Retention of Doctors on Remote Islands: A Systematic Review

Miki Yamauchi, Jun Watanabe, Yoshikazu Kawazuma, Kazuhiko Kotani

Article type: Review
Article ID: 2025.J048
Published: 2025
Advance online publication: May 01, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J048

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Clinical Significance of miR-4638-5p in Patients with Sepsis and Its Regulatory Role in the LPS-Induced Inflammatory Response

Yuanming Bai, Jing Yang, Xin Liu, Jianyuan Huang

Article type: Regular Contribution
Article ID: 2025.J045
Published: 2025
Advance online publication: April 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J045

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KDM6B Regulates BMP2 to Promote Osteoblast Differentiation and Ameliorates Alcohol-Induced Osteoporosis

Dechun Li, Yanguo Wang, Bo Zou, Yannan Bi, Guocen Zheng, Di Wu

Article type: Regular Contribution
Article ID: 2025.J046
Published: 2025
Advance online publication: April 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J046

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FGF21 Activates Autophagy to Ameliorate Lipid Accumulation in NAFLD

Xuexin Xu, Jiayin Ren, Cuili Gong

Article type: Regular Contribution
Article ID: 2025.J044
Published: 2025
Advance online publication: April 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J044

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LncRNA ACTA2-AS1 Inhibits Tumorigenesis of Prostate Cancer by Maintaining ACTA2 Expression

Chang-wei Peng, Pei-li Ma, Hai-tao Dai

Article type: Regular Contribution
Article ID: 2025.J042
Published: 2025
Advance online publication: March 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J042

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Tenascin C Enhances the Development of Papillary Thyroid Carcinoma and has Diagnostic Significance in Papillary Thyroid Microcarcinoma

Qiwei Du, Minghe Zhang, Yuqing Huang, Ziqiang Wang, Nian Liu, Rongguo ...

Article type: Regular Contribution
Article ID: 2025.J043
Published: 2025
Advance online publication: March 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J043

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Retraction: Clinical Value of MiR-636 in Postmenopausal Osteoporosis and Its Role in the Progression of Osteoporosis

Zhengliang Ru, Zhong Tian, Yutong Yang, Lusha Chen, Liandi Wang, Xue P ...

Article type: Regular Contribution
Article ID: 2024.J118
Published: 2024
Advance online publication: November 07, 2024

DOIhttps://doi.org/10.1620/tjem.2024.J118

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Tubacin Decelerates TGF-β1-Induced Pro-Fibrotic Effects on Human Dermal Fibroblasts by Regulating HDAC6-Mediated Deacetylation of α-Tubulin and Hsp90

Yanli Wang, Liu Yang, Tao Wang, Xiuli Li, Xin Zhang

Article type: Regular Contribution
Article ID: 2025.J040
Published: 2025
Advance online publication: March 20, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J040

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1.25(OH)2D3 is Involved in the Regulation of Caspase-3/GSDME Pathway-Mediated Cellular Pyroptosis on Kidneys of Rats with Diabetic Nephropathy

Yuxin Lu, Xi Chen, Lu Wan, Yuchi Qian, Yin Yu, Qin Gao, Lei Liu, Lijua ...

Article type: Regular Contribution
Article ID: 2025.J041
Published: 2025
Advance online publication: March 20, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J041

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Impacts of High-Intensity One-Year Respiratory Muscle Exercise on Respiratory Muscle Force and Dyspnea at Various Body Trunk Angles in a Tetraplegic Patient

Tatsuma Okazaki, Ryo Takahashi, Taruhi Matsui, Midori Miyagi, Takahiro ...

Article type: Case
Article ID: 2025.J037
Published: 2025
Advance online publication: March 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J037

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LncRNA-CR848007.6 Affects Insulin Secretion by Regulating Cell Apoptosis and DNA Damage in Cadmium-Exposed Pancreatic β Cells and is a Novel Biomarker in Patients with Diabetes

Zhiheng Zhou, Shengqing Zhou, Hongda Guo

Article type: Regular Contribution
Article ID: 2025.J038
Published: 2025
Advance online publication: March 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J038

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Wnt2 Expression in Cancer-Associated Fibroblasts Precedes Lymph Node Metastasis in Orthotopic Transplantation Mouse Model of Colorectal Cancer

Hideaki Karasawa, Keigo Murakami, Koh Miura, Hiroyuki Sasaki, Tomoyuki ...

Article type: Regular Contribution
Article ID: 2025.J039
Published: 2025
Advance online publication: March 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J039

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Clinical Significance and Biological Role of LncRNA HCG11 in Diabetic Retinopathy

Jiawen Ling, Jianli Ma, Zhencheng Wu, Xianmi Lin, Chaohui Zhu, Xiang X ...

Article type: Regular Contribution
Article ID: 2025.J033
Published: 2025
Advance online publication: March 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J033

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Effects of Phosphodiesterase-3 Inhibitor in the Management of Left Heart Failure in Extremely Low-Birth-Weight Infants with Simple Aortic Coarctation

Hideyuki Hawaka, Katsuaki Toyoshima, Tomoko Saito, Tomoyuki Shimokaze, ...

Article type: Case
Article ID: 2025.J034
Published: 2025
Advance online publication: March 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J034

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PLOD3 Promotes Head and Neck Squamous Cell Carcinoma Progress via Regulation of P38 MAPK Signal Pathway

Junxia Qiao, Na Guo, Congcong Wei

Article type: Regular Contribution
Article ID: 2025.J035
Published: 2025
Advance online publication: March 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J035

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Berberine Improves ox-LDL-Induced Macrophage Efferocytosis Dysfunction and Alleviates Inflammation via the PPARγ/LXRα Pathway

Xiangli Shen, Yushan Chen, Lili Yu, Junmeng Zheng, Shasha Shang, Jianr ...

Article type: Regular Contribution
Article ID: 2025.J036
Published: 2025
Advance online publication: March 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J036

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Formononetin Inhibits the Development of Lung Cancer by Targeting HK1 to Reduce Glycolysis Levels

Jingxu Han, Yadong Yuan

Article type: Regular Contribution
Article ID: 2025.J024
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J024

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The Effects of Cognitive Behavioral Stress Management on Loneliness, Spiritual Well-Being, Anxiety, and Depression in Patients with Unresectable Advanced Gastric Carcinoma: A Randomized, Controlled Study

Shuli Xia

Article type: Regular Contribution
Article ID: 2025.J025
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J025

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Effect of Dexmedetomidine Plus Propofol versus Propofol Alone on Postoperative Anxiety and Depression, Efficacy, and Satisfaction in Patients who Undergo Painless Induced Abortion

Luxin Wei, Xiaojing Li, Teng Li, Ye Dong, Lianpo Zhang

Article type: Regular Contribution
Article ID: 2025.J026
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J026

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First Report on Ovarian Tissue Cryopreservation for A 6-Year-Old Girl with Non-Mosaic Turner Syndrome (45, X) in Japan: A Case Report

Wakaba Miyamoto, Yusuke Nakamura, Hiromitsu Hattori, Noriyuki Okuyama, ...

Article type: Case
Article ID: 2025.J027
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J027

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Text Mining-Based Drug Discovery and MAPK14, STAT3, VEGFA as Novel Candidate Genes in Post-Tuberculosis Tracheobronchial Stenosis

Wentao Li, Tshetiz Dahal, Guangnan Liu

Article type: Regular Contribution
Article ID: 2025.J028
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J028

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Minimum Invasive Treatment for Patients with Dermoid Cyst with Facelift Procedure: Case Reports and Scoping Literature Review

Nobuo Ohta, Takahiro Suzuki, Naoya Noguchi, Yutaka Tateda, Akina Shiro ...

Article type: Case
Article ID: 2025.J029
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J029

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Comparison of Online with Offline Cognitive-Behavioral Stress Caring Program in Prostate Cancer Survivors after Prostatectomy: A Prospective, Propensity Score-Matched, Cohort Study

Hong Qu, Bingbing Song, Yang Lin, Jiao Liu

Article type: Regular Contribution
Article ID: 2025.J030
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J030

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Characteristics and Death Circumstances on Emergency Admission of Older Patients Receiving Medical and Long-term Care at Home or Nursing Home: Analysis of a Nationwide Administrative Database in Japan

Ayami Matsumura, Kunio Tarasawa, Kiyohide Fushimi, Kenji Fujimori

Article type: Regular Contribution
Article ID: 2025.J031
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J031

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Detection of Glaucomatous Visual Fields Using a Newly Developed Device with Retinal Projection Technology

Satoru Tsuda, Hiroshi Kunikata, Makoto Ishikawa, Airi Takagi, Takeshi ...

Article type: Regular Contribution
Article ID: 2025.J032
Published: 2025
Advance online publication: February 27, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J032

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Kampo Prescriptions for Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Secondary Analysis of Nationwide Survey by JSOG Women’s Health Care Committee

Takashi Takeda, Kana Yoshimi, Fumi Inoue, Tamami Odai, Nahoko Shirato, ...

Article type: Regular Contribution
Article ID: 2025.J019
Published: 2025
Advance online publication: February 21, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J019

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Impact of Telework on Health and Lifestyle Changes During the COVID-19 Pandemic in Japan

Genki Shinoda, Fumiko Matsuzaki, Fumihiko Ueno, Mami Ishikuro, Keiko M ...

Article type: Regular Contribution
Article ID: 2025.J014
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J014

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Predictive Value of LncRNA TUG1 for Complications after Caesarean Section with Scarred Uterus

Lihua Tang, Shuying Li, Huaying Zhu, Xiaoli Ma, Yanfang Wu

Article type: Regular Contribution
Article ID: 2025.J015
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J015

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Endoscopic Surgery for Facial Subcutaneous and Nasal Submucosal Abscesses in a Child

Tomotaka Hemmi, Shuji Chiba, Kazuhiro Nomura

Article type: Case
Article ID: 2025.J016
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J016

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Hounsfield Unit Comparison of Opposite Hemispheres in Computed Tomography for Early Diagnosis of Ischemic Stroke

Selcuk Coskun, Serkan Demircan, Gul Pamukcu Gunaydin, Karabekir Ercan

Article type: Regular Contribution
Article ID: 2025.J017
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J017

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Proactive Mumps Immunization Strategies of Local Authorities, Subsidy Policies Based on Citizen-Involved Municipal Collaboration by Sendai City

Natsuo Yamamoto

Article type: Regular Contribution
Article ID: 2025.J018
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J018

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Curcuma Aeruginosa Roxb. [C.zedoaria non Rosc.] Inhibits Human Papillomavirus-Related Cervical Cancer via Dipeptidyl Peptidase IV

Yue Zhu, Hui Cheng, Min Xu, Guimei Li, Yanling Cui

Article type: Regular Contribution
Article ID: 2025.J020
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J020

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Outcomes of Chemotherapy for Advanced Esophageal Squamous Cell Carcinoma: A Study Using Real-World Data

Tomoyuki Iwasaki, Masanobu Takahashi, Kota Ouchi, Keigo Komine, Yuki K ...

Article type: Regular Contribution
Article ID: 2025.J021
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J021

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Mechanisms Promoting Tumor Progression and Angiogenesis in Retinoblastoma: OTX2 Enhances RTN4 Transcription

Lei Xi, Wentao Li, Baodi Deng, Feng Zhao

Article type: Regular Contribution
Article ID: 2025.J022
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J022

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Fructus Gardenia Extract Improves Cerebral Ischemia-Reperfusion Injury via RIPK1-RIPK3-MLKL Axis

Shengyu Jin, Ke Wang, Zhangfeng Shen, Bing Hu, Qian Dou, Dongdong Xu, ...

Article type: Regular Contribution
Article ID: 2025.J023
Published: 2025
Advance online publication: February 13, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J023

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Diagnostic Value of Contrast-Enhanced Ultrasound Combined with MiR-125b-5p in Acute Cerebral Infarction and Its Correlation with Carotid Plaque Neovascularization

Qianqian Pei, Renyi Zhu, Yafei Yang

Article type: Regular Contribution
Article ID: 2025.J011
Published: 2025
Advance online publication: February 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J011

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Therapeutic and Diagnostic Potential of MicroRNAs in Children with Attention-Deficit Hyperactivity Disorder

Jinhui Wu, Ping Li, Hong Luo, You Lu

Article type: Review
Article ID: 2025.J012
Published: 2025
Advance online publication: February 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J012

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Acupuncture Alleviates Cognitive Dysfunction after Ischemic Stroke by Regulating the MiR-181a-5p/TFAM Axis

Chi Ma, Xu Fan

Article type: Regular Contribution
Article ID: 2025.J013
Published: 2025
Advance online publication: February 06, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J013

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