The Tohoku Journal of Experimental Medicine

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Preservation of Inner Ear Function in a Case of Vestibular Fistula Caused by Cholesteatoma Using the Underwater Technique

Yuki Kishima, Ryoukichi Ikeda, Aya Katsura, Iori Kusaka, Kiyoto Shiga

Article type: Case
Article ID: 2025.J119
Published: 2025
Advance online publication: October 09, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J119

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Identification of KLHL35, WDR72, and WDR78 as Prognostic Biomarkers in Colorectal Cancer

Jiayou Ye, Tingting Zhang, Guangsheng Wang, Guofeng Bian, Aijun Chen, ...

Article type: Regular Contribution
Article ID: 2025.J121
Published: 2025
Advance online publication: October 09, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J121

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KLF5 Alleviates Excessive Autophagy-Induced Podocyte Injury by Enhancing ITCH-Mediated Ubiquitination of ACTR2

Xianchu Lin, Huirong Lin, Man Luo, Jun Han, Yan Hu, Shilong Xiang, Zej ...

Article type: Regular Contribution
Article ID: 2025.J122
Published: 2025
Advance online publication: October 09, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J122

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Acupuncture Ameliorates Cognitive Dysfunction by Modulating the Apoptosis of Hippocampal Neuron in Severe Hand Foot and Mouth Disease Infant Rats Through the p38 MAPK/CREB Pathway

Zongtao Wu, Hongjiao Jin, Biqin Shuai, Xiang Zhang, San Wang, Lan Chen ...

Article type: Regular Contribution
Article ID: 2025.J102
Published: 2025
Advance online publication: October 02, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J102

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Expressions of VEGF, Vasohibin-1, and Vasohibin-2 in Benign Parotid Gland Tumors

Yutaka Tateda, Takahiro Suzuki, Teruyuki Sato, Kazue Ise, Hiroki Shima ...

Article type: Regular Contribution
Article ID: 2025.J115
Published: 2025
Advance online publication: October 02, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J115

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The Predictive Value of miR-205-5p for Abdominal Adhesion and Postpartum Complications in Women with Scarred Uterus

Jinhui Feng, Fang Li, Jinyun Meng, Jumei Xiao

Article type: Regular Contribution
Article ID: 2025.J110
Published: 2025
Advance online publication: September 25, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J110

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Inhibition of miR-199b-5p Suppresses the Tuberculosis-Induced Inflammation in Spinal Tuberculosis via Targeting Gcnt2

Aierpati Yusufu, Runze Du, Muradil Mardan, Xuyang Xie, Xiaoyu Cai, Tao ...

Article type: Regular Contribution
Article ID: 2025.J111
Published: 2025
Advance online publication: September 25, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J111

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Effectiveness of Information-Motivation-Behavioral Skills Model of Hypothyroidism Self-Management Integrated into Prenatal Care in Pregnant Women with Newly Diagnosed Hypothyroidism

He Li, Dong-Fang Shao, Jing Zheng, Wen-Qian Chen, Ying Xie

Article type: Regular Contribution
Article ID: 2025.J112
Published: 2025
Advance online publication: September 25, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J112

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Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulation and Hepatocellular Carcinoma Progression

Haitao Jiang, Weibin Hu, Lingling Yuan

Article type: Regular Contribution
Article ID: 2025.J116
Published: 2025
Advance online publication: September 25, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J116

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Sanqi Oral Solution Containing Serum Ameliorates C5b-9 Induced Podocyte Injury via the Endoplasmic Reticulum Stress/Unfolded Protein Response Dependent Pathway

Yongdong Du, Ruitao Cai, Zhibin Lin, Zhengdong Wu

Article type: Regular Contribution
Article ID: 2025.J101
Published: 2025
Advance online publication: September 18, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J101

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MicroRNA-940 Induces Apoptosis of HTR8-S/Vneo Cells in Intrahepatic Cholestasis of Pregnancy by Regulating RhoA

Chunyan Yu, Chengnan Zhang, Lei Zhang, Jinyu Gu, Li Qin

Article type: Regular Contribution
Article ID: 2025.J104
Published: 2025
Advance online publication: September 18, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J104

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Expression of LINC01123 in Patients with Hypertension and Its Damage to Endothelial Cells

Yuanyuan Su, Runxi Xu, Shuqi Huang, Chong Yang, Yunhua Hao

Article type: Regular Contribution
Article ID: 2025.J105
Published: 2025
Advance online publication: September 18, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J105

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Association between P2RX7 rs7958311 Polymorphism and Labor Analgesia in Primiparas

Ying Wang, Guantong Zhou, Lijia Long, Li Wan, Yan Hou, Churong Wang

Article type: Regular Contribution
Article ID: 2025.J107
Published: 2025
Advance online publication: September 18, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J107

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MiR-126-3p Inhibits the Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome by Targeting SLC7A5

Baoqin Liu, Qiong Peng

Article type: Regular Contribution
Article ID: 2025.J113
Published: 2025
Advance online publication: September 18, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J113

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Novel Biallelic TECRL Gene Variants Associated with Familial Catecholaminergic Polymorphic Ventricular Tachycardia in a Chinese Family with a History of Sudden Cardiac Death

Ruihua Li, Ning Li, Chengxun Lv, Xingya Xu, Jianshu Song, Rujiang Bai, ...

Article type: Regular Contribution
Article ID: 2025.J109
Published: 2025
Advance online publication: September 11, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J109

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Anti-TNF-α Treatment Improves the Live Birth Rate and Reduces the Risk of Premature Delivery in Patients with Recurrent Spontaneous Abortion

Shuxia Chen, Yuan Li, Chao Sun, Jiecheng Yang, Shaoying Li, Qiang Feng ...

Article type: Regular Contribution
Article ID: 2025.J103
Published: 2025
Advance online publication: September 04, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J103

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Epidural Anesthesia Using Mixed Reality Technology: A Successful Case Report of Spinal Visualization in a Patient with Difficult Epidural Anesthesia

Shun Nagashima, Tatsuya Hayasaka, Kazunori Sato, Akira Takagi, Makiko ...

Article type: Case
Article ID: 2025.J098
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J098

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A Traditional Japanese Samurai Movement Rei-ho as a Knee Extension Strength Training: A Randomized Controlled Study

Ayaka Ogasawara, Akira Sato, Ryoichi Nagatomi

Article type: Regular Contribution
Article ID: 2025.J099
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J099

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Blood Resolvin D1 is Associated with a Lower Acute Myocardial Infarction Risk

Junfeng Song, Jing Zhang, Qiang Feng, Yangxia Huang, Yanni Huang, Yunz ...

Article type: Regular Contribution
Article ID: 2025.J100
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J100

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Histone Lactylation Promotes Proliferation and Migration of TNBC Cells via Upregulating MCM7 Transcription

Fei Xiao, Chaoxian Wang, Sili Jin, Ziran Zhang, Xingxia Yang, Guangfa ...

Article type: Regular Contribution
Article ID: 2025.J096
Published: 2025
Advance online publication: July 31, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J096

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Inhibition of Regulator of G Protein Signaling 20 Reduces Cell Proliferation, Invasion and Migration by Activating the Hippo Pathway in Cutaneous Melanoma

Yi Zhang, Mengbi Gong

Article type: Regular Contribution
Article ID: 2025.J097
Published: 2025
Advance online publication: July 31, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J097

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At-Home Deaths and Regional Factors in Japan

Nayuta Shimizu, Kazuhiko Kotani

Article type: Regular Contribution
Article ID: 2025.J094
Published: 2025
Advance online publication: July 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J094

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The Effects of Low-Dose Dexamethasone on Cell Kinetics, Cytokine Productivity and Natural Killer Cell Cytotoxicity in Murine Lymphoid Organs in Vivo

Hideaki Ebana, Shin Kurosawa, Rieko Oishi, Shinju Obara, Satoki Inoue

Article type: Regular Contribution
Article ID: 2025.J095
Published: 2025
Advance online publication: July 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J095

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Drp1-Dependent Mitochondrial Fission is Involved in Adriamycin Resistance in Gastric Cancer Cells: A Perspective from the BATF2/p53/ERK Regulatory Axis

Wei Yang, Rong Zeng, Jianlin Song, Ning Ma, Wenchuan Zhu, Tianyan Fu, ...

Article type: Regular Contribution
Article ID: 2025.J091
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J091

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SPARCL1 Regulates Proliferation and Angiogenesis of HUVECs Through the DLL4/NOTCH1 Pathway in Preeclampsia

Lingfang Liu, Yan Gao, Li Ao, Chao Yang, Wanyu Zhao, Chunmei Deng, Qia ...

Article type: Regular Contribution
Article ID: 2025.J092
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J092

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FOXO1 Targets LHX8 1 to Promote Granulosa Cell Apoptosis

Lan Luo, Man Luo, Licen Xie, Mi Tang, Minhui Luo, Jialan Cui

Article type: Regular Contribution
Article ID: 2025.J093
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J093

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Association between Iron Intake and Mental Health in Older Adults: The Yamagata Cohort Study

Yuuki Tanaka, Tsuneo Konta, Haruka Ono, Yoshiyuki Ueno, Kaori Sakurada

Article type: Regular Contribution
Article ID: 2025.J089
Published: 2025
Advance online publication: July 10, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J089

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The Effects of Presurgical Infant Orthopedic Treatment on the Maxillary Arch, Craniofacial Form, and Lip Morphology of Patients with Unilateral Cleft Lip and Palate, Aged up to 5 Years

Mika Unno, Shinobu Tsuchiya, Chieko Miura, Akimitsu Sato, Yoshimichi I ...

Article type: Regular Contribution
Article ID: 2025.J090
Published: 2025
Advance online publication: July 10, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J090

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The Association of High Mobility Group Box-1 with Sepsis Susceptibility and Mortality Risk: A Meta-Analysis

Shuqi Yang, Xinfeng Song, Xingqian Jin, Xu Huang

Article type: Review
Article ID: 2025.J085
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J085

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Blue Light-Blocking Glasses Attenuate Light-Induced Melatonin Suppression in Healthy Japanese Adults

Yuma Onodera, Naoko Kubota, Nagomi Miyagi, Noriko Matsuura, Shinya Mur ...

Article type: Regular Contribution
Article ID: 2025.J086
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J086

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KLF16-Induced Increase of GARS Promotes Glycolysis in Hepatocellular Carcinoma by Stabilizing FOXK1

Jinghui Wang, Ruijuan Fan, Jun Li, Hanbo Qiu, Lizhu Lin

Article type: Regular Contribution
Article ID: 2025.J087
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J087

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Elevated Expression of EphA10 in Gastric Cancer Tissues: A Potential Biomarker for Tumor Metastasis and Poor Survival

Dongni Leng, Kangjie Yu, Shiya Weng, Jiaxin Chai, Jiandong Wang, Wei D ...

Article type: Regular Contribution
Article ID: 2025.J088
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J088

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Comparative Analysis of Perinatal Outcomes in Type 1 and Type 2 Diabetes Pregnancies: A Retrospective Study

Mai Sue-Nagumo, Akihito Morita, Daisuke Higeta, Maki Inoue, Aya Osaki, ...

Article type: Regular Contribution
Article ID: 2025.J080
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J080

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Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model

Ting Zhou, Shanshan Xu, Juan Tang, Xiaomei Han, Yu Jiang, Huaying Chen

Article type: Regular Contribution
Article ID: 2025.J081
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J081

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Ligustilide Promotes Gastric Cancer Cell Apoptosis via Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction and Autophagy

Hanqing Liu, Qiong Xiang, Shasha Mei, Jingyi Yang, Dan Ma, Bowen Wang, ...

Article type: Regular Contribution
Article ID: 2025.J082
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J082

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MiR-324-3p Drives Malignant Behaviors of Tumor Cells by Promoting M2 Macrophage Polarization in Laryngeal Squamous Cell Carcinoma

Jinqiao Huang, Xiufen Chen, Xian Chen

Article type: Regular Contribution
Article ID: 2025.J083
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J083

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Dysregulated Long Non-Coding RNA DANCR in Polycystic Ovary Syndrome Drives Granulosa Cell Apoptosis and Contributes to Ovarian Dysfunction via MiR-185-5p

Jie An, Qin Zhou, Xueqian Liu, Jingjing Ren, Yijiao Cheng, Yanjiao Liu ...

Article type: Regular Contribution
Article ID: 2025.J084
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J084

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Hsa-miR-485-3p can be Involved in the Progression of Diabetic Retinopathy by Targeting IL1RN

Jiao Wu, Tanwei Wei, Sha Zheng, Mei Long, Yi Chen, Yongguang Yuan

Article type: Regular Contribution
Article ID: 2025.J055
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J055

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Cimetidine for Pediatric Use in Japan: Rising Prescriptions for a New Indication

Karin Oshima, Eisuke Inage, Shun Toriumi, Kenji Oishi, Hiromichi Yamad ...

Article type: Regular Contribution
Article ID: 2025.J075
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J075

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Bacillus Licheniformis Capsules 1 (Live) Modulates Gut Microbiota and Enhances Immune Function in Chemotherapy Patients with Non-Small Cell Lung Cancer

Jie Yu, Hongcan Shi, Xiaolin Wang, Shichun Lu, Chao Sun, Weiguo Jin, Y ...

Article type: Regular Contribution
Article ID: 2025.J076
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J076

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Evaluation and Comparison of Intervertebral Disc Degeneration Models Induced by Cervical Instability in Rats

Yutao Wang, Jiaxin Chen, Dinghao Zhang, Haoshan Lin, Xinjun Fan, Sheny ...

Article type: Regular Contribution
Article ID: 2025.J077
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J077

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Immunolocalization of CD28, CTLA-4 and CD80 in Non-Small Cell Lung Carcinoma: Combined CD28/CTLA-4/CD80 Status is a Potent Prognostic Factor of These Patients

Takashi Sato, Kiyoshi Takagi, Chihiro Inoue, Mitsunori Higuchi, Nobuko ...

Article type: Regular Contribution
Article ID: 2025.J078
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J078

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HSPA1B Regulates the Expression of Blood Pressure Related Genes in Human Umbilical Vein Endothelial Cells (HUVEC) and Its Mechanism

Li Zhong, Bing Zhang, Kadeer Nafeisha, Wushouer Xilinguli, Yunusi Kure ...

Article type: Regular Contribution
Article ID: 2025.J079
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J079

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Analysis of the Correlation between SLC6A4 rs1042173 Gene Polymorphisms and the Effect of Sufentanil Epidural Labor Analgesia in Pregnant Women

Xiaoyan Ma, Jie Tang, Yiyi Shen, Bei Wang, Jie Liu, Xingjie Wu

Article type: Regular Contribution
Article ID: 2025.J070
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J070

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Assessment of the Physical Properties, drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres

Fei Guo, Min Xu, Baosheng Ren, Fengxuan Han

Article type: Regular Contribution
Article ID: 2025.J071
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J071

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The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirof ...

Article type: Regular Contribution
Article ID: 2025.J072
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J072

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Age-Specific Trends and Health Status of Children Aged 12-19 Years with Specified Chronic Pediatric Diseases in Japan – Insights from a National Database Study

Erika Kuwahara, Akinori Moriichi, Hitoshi Kato

Article type: Regular Contribution
Article ID: 2025.J073
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J073

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Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder

Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu M ...

Article type: Regular Contribution
Article ID: 2025.J074
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J074

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Functional Mechanism and Clinical Implications of MiR-378a-3p in Femoral Shaft Fracture Healing Processes

Yanlong Shao, Xiaojun Min, Fangyuan Zhang, Na Zhao, Xi Wu, Rui Chen, S ...

Article type: Regular Contribution
Article ID: 2025.J065
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J065

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Detection of Cataract with a New Perimetry Method Using Retinal Projection Technology

Takeshi Yabana, Naoko Takada, Satoru Tsuda, Makoto Ishikawa, Mai Yamaz ...

Article type: Regular Contribution
Article ID: 2025.J066
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J066

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