The Tohoku Journal of Experimental Medicine

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Epidural Anesthesia Using Mixed Reality Technology: A Successful Case Report of Spinal Visualization in a Patient with Difficult Epidural Anesthesia

Shun Nagashima, Tatsuya Hayasaka, Kazunori Sato, Akira Takagi, Makiko ...

Article type: Case
Article ID: 2025.J098
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J098

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A Traditional Japanese Samurai Movement Rei-ho as a Knee Extension Strength Training: A Randomized Controlled Study

Ayaka Ogasawara, Akira Sato, Ryoichi Nagatomi

Article type: Regular Contribution
Article ID: 2025.J099
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J099

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Blood Resolvin D1 is Associated with a Lower Acute Myocardial Infarction Risk

Junfeng Song, Jing Zhang, Qiang Feng, Yangxia Huang, Yanni Huang, Yunz ...

Article type: Regular Contribution
Article ID: 2025.J100
Published: 2025
Advance online publication: August 14, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J100

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Histone Lactylation Promotes Proliferation and Migration of TNBC Cells via Upregulating MCM7 Transcription

Fei Xiao, Chaoxian Wang, Sili Jin, Ziran Zhang, Xingxia Yang, Guangfa ...

Article type: Regular Contribution
Article ID: 2025.J096
Published: 2025
Advance online publication: July 31, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J096

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Inhibition of Regulator of G Protein Signaling 20 Reduces Cell Proliferation, Invasion and Migration by Activating the Hippo Pathway in Cutaneous Melanoma

Yi Zhang, Mengbi Gong

Article type: Regular Contribution
Article ID: 2025.J097
Published: 2025
Advance online publication: July 31, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J097

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At-Home Deaths and Regional Factors in Japan

Nayuta Shimizu, Kazuhiko Kotani

Article type: Regular Contribution
Article ID: 2025.J094
Published: 2025
Advance online publication: July 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J094

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The Effects of Low-Dose Dexamethasone on Cell Kinetics, Cytokine Productivity and Natural Killer Cell Cytotoxicity in Murine Lymphoid Organs in Vivo

Hideaki Ebana, Shin Kurosawa, Rieko Oishi, Shinju Obara, Satoki Inoue

Article type: Regular Contribution
Article ID: 2025.J095
Published: 2025
Advance online publication: July 24, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J095

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Drp1-Dependent Mitochondrial Fission is Involved in Adriamycin Resistance in Gastric Cancer Cells: A Perspective from the BATF2/p53/ERK Regulatory Axis

Wei Yang, Rong Zeng, Jianlin Song, Ning Ma, Wenchuan Zhu, Tianyan Fu, ...

Article type: Regular Contribution
Article ID: 2025.J091
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J091

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SPARCL1 Regulates Proliferation and Angiogenesis of HUVECs Through the DLL4/NOTCH1 Pathway in Preeclampsia

Lingfang Liu, Yan Gao, Li Ao, Chao Yang, Wanyu Zhao, Chunmei Deng, Qia ...

Article type: Regular Contribution
Article ID: 2025.J092
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J092

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FOXO1 Targets LHX8 1 to Promote Granulosa Cell Apoptosis

Lan Luo, Man Luo, Licen Xie, Mi Tang, Minhui Luo, Jialan Cui

Article type: Regular Contribution
Article ID: 2025.J093
Published: 2025
Advance online publication: July 17, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J093

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Association between Iron Intake and Mental Health in Older Adults: The Yamagata Cohort Study

Yuuki Tanaka, Tsuneo Konta, Haruka Ono, Yoshiyuki Ueno, Kaori Sakurada

Article type: Regular Contribution
Article ID: 2025.J089
Published: 2025
Advance online publication: July 10, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J089

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The Effects of Presurgical Infant Orthopedic Treatment on the Maxillary Arch, Craniofacial Form, and Lip Morphology of Patients with Unilateral Cleft Lip and Palate, Aged up to 5 Years

Mika Unno, Shinobu Tsuchiya, Chieko Miura, Akimitsu Sato, Yoshimichi I ...

Article type: Regular Contribution
Article ID: 2025.J090
Published: 2025
Advance online publication: July 10, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J090

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The Association of High Mobility Group Box-1 with Sepsis Susceptibility and Mortality Risk: A Meta-Analysis

Shuqi Yang, Xinfeng Song, Xingqian Jin, Xu Huang

Article type: Review
Article ID: 2025.J085
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J085

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Blue Light-Blocking Glasses Attenuate Light-Induced Melatonin Suppression in Healthy Japanese Adults

Yuma Onodera, Naoko Kubota, Nagomi Miyagi, Noriko Matsuura, Shinya Mur ...

Article type: Regular Contribution
Article ID: 2025.J086
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J086

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KLF16-Induced Increase of GARS Promotes Glycolysis in Hepatocellular Carcinoma by Stabilizing FOXK1

Jinghui Wang, Ruijuan Fan, Jun Li, Hanbo Qiu, Lizhu Lin

Article type: Regular Contribution
Article ID: 2025.J087
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J087

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Elevated Expression of EphA10 in Gastric Cancer Tissues: A Potential Biomarker for Tumor Metastasis and Poor Survival

Dongni Leng, Kangjie Yu, Shiya Weng, Jiaxin Chai, Jiandong Wang, Wei D ...

Article type: Regular Contribution
Article ID: 2025.J088
Published: 2025
Advance online publication: July 03, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J088

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Comparative Analysis of Perinatal Outcomes in Type 1 and Type 2 Diabetes Pregnancies: A Retrospective Study

Mai Sue-Nagumo, Akihito Morita, Daisuke Higeta, Maki Inoue, Aya Osaki, ...

Article type: Regular Contribution
Article ID: 2025.J080
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J080

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Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model

Ting Zhou, Shanshan Xu, Juan Tang, Xiaomei Han, Yu Jiang, Huaying Chen

Article type: Regular Contribution
Article ID: 2025.J081
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J081

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Ligustilide Promotes Gastric Cancer Cell Apoptosis via Endoplasmic Reticulum Stress-Induced Mitochondrial Dysfunction and Autophagy

Hanqing Liu, Qiong Xiang, Shasha Mei, Jingyi Yang, Dan Ma, Bowen Wang, ...

Article type: Regular Contribution
Article ID: 2025.J082
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J082

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MiR-324-3p Drives Malignant Behaviors of Tumor Cells by Promoting M2 Macrophage Polarization in Laryngeal Squamous Cell Carcinoma

Jinqiao Huang, Xiufen Chen, Xian Chen

Article type: Regular Contribution
Article ID: 2025.J083
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J083

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Dysregulated Long Non-Coding RNA DANCR in Polycystic Ovary Syndrome Drives Granulosa Cell Apoptosis and Contributes to Ovarian Dysfunction via MiR-185-5p

Jie An, Qin Zhou, Xueqian Liu, Jingjing Ren, Yijiao Cheng, Yanjiao Liu ...

Article type: Regular Contribution
Article ID: 2025.J084
Published: 2025
Advance online publication: June 26, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J084

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Hsa-miR-485-3p can be Involved in the Progression of Diabetic Retinopathy by Targeting IL1RN

Jiao Wu, Tanwei Wei, Sha Zheng, Mei Long, Yi Chen, Yongguang Yuan

Article type: Regular Contribution
Article ID: 2025.J055
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J055

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Cimetidine for Pediatric Use in Japan: Rising Prescriptions for a New Indication

Karin Oshima, Eisuke Inage, Shun Toriumi, Kenji Oishi, Hiromichi Yamad ...

Article type: Regular Contribution
Article ID: 2025.J075
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J075

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Bacillus Licheniformis Capsules 1 (Live) Modulates Gut Microbiota and Enhances Immune Function in Chemotherapy Patients with Non-Small Cell Lung Cancer

Jie Yu, Hongcan Shi, Xiaolin Wang, Shichun Lu, Chao Sun, Weiguo Jin, Y ...

Article type: Regular Contribution
Article ID: 2025.J076
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J076

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Evaluation and Comparison of Intervertebral Disc Degeneration Models Induced by Cervical Instability in Rats

Yutao Wang, Jiaxin Chen, Dinghao Zhang, Haoshan Lin, Xinjun Fan, Sheny ...

Article type: Regular Contribution
Article ID: 2025.J077
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J077

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Immunolocalization of CD28, CTLA-4 and CD80 in Non-Small Cell Lung Carcinoma: Combined CD28/CTLA-4/CD80 Status is a Potent Prognostic Factor of These Patients

Takashi Sato, Kiyoshi Takagi, Chihiro Inoue, Mitsunori Higuchi, Nobuko ...

Article type: Regular Contribution
Article ID: 2025.J078
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J078

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HSPA1B Regulates the Expression of Blood Pressure Related Genes in Human Umbilical Vein Endothelial Cells (HUVEC) and Its Mechanism

Li Zhong, Bing Zhang, Kadeer Nafeisha, Wushouer Xilinguli, Yunusi Kure ...

Article type: Regular Contribution
Article ID: 2025.J079
Published: 2025
Advance online publication: June 19, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J079

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Analysis of the Correlation between SLC6A4 rs1042173 Gene Polymorphisms and the Effect of Sufentanil Epidural Labor Analgesia in Pregnant Women

Xiaoyan Ma, Jie Tang, Yiyi Shen, Bei Wang, Jie Liu, Xingjie Wu

Article type: Regular Contribution
Article ID: 2025.J070
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J070

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Assessment of the Physical Properties, drug Loadability and Release Profile, and Biocompatibility of UniPearls® Microspheres

Fei Guo, Min Xu, Baosheng Ren, Fengxuan Han

Article type: Regular Contribution
Article ID: 2025.J071
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J071

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The Utility of a Modified Data-Driven Motion Correction Method Incorporating Computed Tomography Positional Data for Positron Emission Tomography

Hayato Odagiri, Hiroshi Watabe, Kentaro Takanami, Nao Yamaguchi, Hirof ...

Article type: Regular Contribution
Article ID: 2025.J072
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J072

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Age-Specific Trends and Health Status of Children Aged 12-19 Years with Specified Chronic Pediatric Diseases in Japan – Insights from a National Database Study

Erika Kuwahara, Akinori Moriichi, Hitoshi Kato

Article type: Regular Contribution
Article ID: 2025.J073
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J073

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Gaze Patterns of Children with Communication Difficulties Associated with Core Symptoms of Autism Spectrum Disorder

Mika Kobayashi, Tomoko Kobayashi, Taku Obara, Akira Narita, Akimitsu M ...

Article type: Regular Contribution
Article ID: 2025.J074
Published: 2025
Advance online publication: June 12, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J074

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Functional Mechanism and Clinical Implications of MiR-378a-3p in Femoral Shaft Fracture Healing Processes

Yanlong Shao, Xiaojun Min, Fangyuan Zhang, Na Zhao, Xi Wu, Rui Chen, S ...

Article type: Regular Contribution
Article ID: 2025.J065
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J065

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Detection of Cataract with a New Perimetry Method Using Retinal Projection Technology

Takeshi Yabana, Naoko Takada, Satoru Tsuda, Makoto Ishikawa, Mai Yamaz ...

Article type: Regular Contribution
Article ID: 2025.J066
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J066

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Cyanoacrylate is still an Effective Surgical strategy for Homeostasis: A Rodent Model of Liver Trauma and Evaluation of Early Wound Healing

Anıl Orhan, Süleyman Demiryas, Engin Hatipoğlu, Karolin Yanar, Nuray ...

Article type: Regular Contribution
Article ID: 2025.J067
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J067

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Sex-Difference in Olfactory Interhemispheric Malformation Caused by Pax6 Haploinsufficiency

Natsumi Joko, Takako Kikkawa, Takayoshi Inoue, Noriko Osumi

Article type: Regular Contribution
Article ID: 2025.J068
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J068

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Brain-Derived Neurotrophic Factor is Negatively Associated with Anxiety and Depression in Psoriasis Patients

Bo Zhang, Manzhao Qu, Yixi Cuomu, Yi Chen

Article type: Regular Contribution
Article ID: 2025.J069
Published: 2025
Advance online publication: June 05, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J069

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An Indolent Aldosterone-Producing Adenoma in a Young Hypertensive Patient Manifested during 7-Year Follow-up

Yuta Tezuka, Yoshikiyo Ono, Yuto Yamazaki, Satoshi Higuchi, Jun Nishik ...

Article type: Case
Article ID: 2025.J060
Published: 2025
Advance online publication: May 29, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J060

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Effects of SCN2A Gene Polymorphism on Drug Response in Han Chinese Children with Epilepsy

Lin Xu, Jie Fan, Yongbiao Zou

Article type: Regular Contribution
Article ID: 2025.J061
Published: 2025
Advance online publication: May 29, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J061

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Curcumin Nano-Formulations with Enhanced Bioavailability and Therapeutic Efficacy for Osteoarthritis Treatment

Fan Zhong, Jinyi Zhang, Lin Teng, Dahai Liu, Yongchuan Xiao, Gang Zhon ...

Article type: Review
Article ID: 2025.J062
Published: 2025
Advance online publication: May 29, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J062

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Predictive Value of Abnormally Expressed Serum MiR-204-5p in Pregnancy during Second Trimester on Subclinical Hypothyroidism

Qian Wang, Jingsong Cheng, Wenjing He, Xiaofeng Li, Jun Ma, Xiaoyan Wa ...

Article type: Regular Contribution
Article ID: 2025.J063
Published: 2025
Advance online publication: May 29, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J063

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Effect of Serum MiR-106a-5p on Vascular Calcification in Dialysis Patients

Hong Zhang, Zhihang Jiang, Lei Xu, Jihong Zhang, Yawei Yuan, Xuanlin L ...

Article type: Regular Contribution
Article ID: 2025.J064
Published: 2025
Advance online publication: May 29, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J064

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A High Ratio of D-1 Dimer to Brain Natriuretic Peptide and Large Right-to-Left Shunt by Contrast-Enhanced Transthoracic Echocardiography as Risk Factors for Cryptogenic Stroke in Patent Foramen Ovale

Fuwang Zhang, Wenfang Cui

Article type: Regular Contribution
Article ID: 2025.J056
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J056

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Effectiveness of Remote Symptom 1 Monitoring and Progressive Muscle Relaxation in Enhancing Well-Being and Quality of Life in Lung Cancer Patients Undergoing Chemotherapy

Yong Jiang, Jing-Ping Yang, Qin Liu

Article type: Regular Contribution
Article ID: 2025.J057
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J057

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Clinical Significance and Biological Role of lncRNA linc00893 in Diabetic Retinopathy

Jingdi Zhang, Wenhan Lu, Dan Xu

Article type: Regular Contribution
Article ID: 2025.J058
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J058

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Clinical Significance and Functional Analysis of miR-487b-3p in Ovarian Cancer

Shixi Zhang, Jing Chen, Qian Gao, Yan Li, Chao Wang

Article type: Regular Contribution
Article ID: 2025.J059
Published: 2025
Advance online publication: May 22, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J059

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Nutritional Modulation Improves the Immune Function of Cervical Carcinoma Patients Receiving Radiotherapy: A Retrospective Analysis of 106 Cases

Jianbo Li, Min Fang

Article type: Regular Contribution
Article ID: 2025.J052
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J052

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Clinical Value and Molecular Mechanism of MiR-411-5p in Coronary Atherosclerosis

Chang Liu, Yingying Wang, Menghao Sun, Tingqi Shi

Article type: Regular Contribution
Article ID: 2025.J053
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J053

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Development and Performance Evaluation of a Novel Mobile X-ray System for Use in Disaster Situations

Masaki Fujisawa, Yohei Inaba, Toshiki Kato, Masatoshi Suzuki, Koichi C ...

Article type: Review
Article ID: 2025.J054
Published: 2025
Advance online publication: May 15, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J054

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Oxymatrine Inhibits PKM2-Mediated Glycolysis and Enhances Cisplatin Sensitivity in Bladder Cancer

Hui Zhang, Jun Li

Article type: Regular Contribution
Article ID: 2025.J049
Published: 2025
Advance online publication: May 08, 2025

DOIhttps://doi.org/10.1620/tjem.2025.J049

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