Annual Meeting of the Japanese Society of Toxicology

Annual Meeting of the Japanese Society of Toxicology

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32nd Annual Meeting of the Japanese Society of Toxicology

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Oral Presentation

Comparison of the sensitivity of various in vivo animal models for detecting the drug-induced QT interval prolongation

Yasuki Akie, Yasue Sakaguchi, Yoshiki tate, Yoshinori Ishiyama, Masaru ...

Session ID: O-15
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.52.0

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Effect of dosing interval between edaravone and cefalotin/glycerol on the nephrotoxicity in rats

Naoki OHYAMA, Shun-ichiro ISHII, Hiroshi SHIBATA, Miyoko OKADA, Yoshim ...

Session ID: O-16
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.53.0

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Gene expression profiling of rat kidneys following dose of edaravone in combination with cefalotin and glycerol

Toshinobu Shimizu, Naoya Masutomi, Shun-ichiro Ishii, Naoki Ohyama, Mi ...

Session ID: O-17
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.54.0

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Protection from liver toxicity induced by lithocholic acid-feeding - Involvement of Cyp3a and hydroxysteroid sulfotransferase -

Hirotaka WATASE, Wataru HORI, Masaaki MIYATA, Kiyoshi NAGATA, Frank GO ...

Session ID: O-18
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.55.0

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Expression of hydroxysteroid sulfotransferase involved in protection against bile acid-induced hepatotoxicity

Masaaki MIYATA, Yoshiki Matsuda, Hiroyuki Tsuchiya, Kiyoshi Nagata, Fr ...

Session ID: O-19
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.56.0

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Bile acids sulfate as a possible early marker of liver toxicity.

Wataru Hori, Tomohiro Mizuki, Masaaki Miyata, Kiyoshi Nagata, Frank J ...

Session ID: O-20
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.57.0

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The role of CYP1 family in metabolic activation of benzo[a]pyrene.

Shigeyuki Uno, Makoto Makishima, Dalton P. Timothy, Nebert W. Daniel

Session ID: O-21
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.58.0

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Induction of Cytochrome P450 isozymes by phenobarbital in pregnant rat and fetal livers and placenta

Noriko Ejiri, Naoki Kiyosawa, Kei-ichi Katayama, Koji Uetsuka, Hiroyuk ...

Session ID: O-22
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.59.0

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Effects of Restricted Feeding on Daily Rhythm of Hepatic P450 Monooxygenase Activities in Male Rats

Jun HIRAO, Shingo ARAKAWA, Kyoko WATANABE, Kazumi ITO, Tadashi FURUKAW ...

Session ID: O-23
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.60.0

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Neonatal Exposure to low dose diethylstilbestrol (DES) alters uterine response to estrogen and incuces multioocyte follicles in prepubescent CD-1 mice

Yuko Matsushima, Jun Kanno

Session ID: O-24
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.61.0

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Effect of perinatal exposure to diethylstilbestrol on mammary differentiation and tumorigenesis in female rats

Katsuhiro MIYAJIMA, Susumu TAKEKOSHI, Kochi KAKIMOTO, Haruko KOIZUMI, ...

Session ID: O-25
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.62.0

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Growth suppressor mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R): down-regulation by androgen in rat prostate and application of novel biomarker for screening of chemicals with androgen-receptor mediated activities.

TOMOYA YAMADA, KIYOKO BANDO, YASUNORI IZAWA, KOICH SAITO, YASUYOSHI OK ...

Session ID: O-26
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.63.0

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Uterotropic assay in immature and ovariectomized female rats –A comparison between oral and subcutaneous administration-

Tomoki Fukuyama, Kouichi Hayashi, Yukari Tajima, Hideaki Fujie, Tsutom ...

Session ID: O-27
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.64.0

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Enigma of oxidative stress in benzene induced hematotoxicity: Answer by thioredoxin-overexpression mouse

Yoko Hirabayashi, Yasushi Kawasaki, Junji Yodoi, Guang-Xun Li, Byung-I ...

Session ID: O-28
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.65.0

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Point mutation in PU.1 in radiation-induced mouse myeloidleukemia

Yasushi Ohmachi, Yoshikazu Kuwahara, Satsuki Tsuji, Hideo Tsuji, Nobuh ...

Session ID: O-29
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.66.0

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Diagnostic Efficiency of Cardiac Troponin T Measurements in Rats with Drug-Induced Myocardial Cell Damage

Tadakazu TAKAHASHI, Toshiyuki SHODA, Yuusuke SUZUKI, Takuya ABE, Shin- ...

Session ID: O-30
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.67.0

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Markers for detecting myocardial damage in rats - From a view of clinical pathology -

Masaaki Kurata, Naoko Yamasaki, Yukiko Sasayama, Takeshi Iidaka, Tamio ...

Session ID: O-31
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.68.0

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Reliability of monophasic action potential as measurement of QT prolongation in anesthetized guinea pig at early drug development stage

Namie BEPPU, Atsushi SASAKI, Mayumi OBO, Seiichi KATAYAMA, Kentaro AND ...

Session ID: O-32
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.69.0

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Comparison of four types of rate-correcting methods for QT interval: which methods can better reflect the inhibition of delayed rectifier K channels in the halothane-anesthetized guinea pigs?

Akira Takahara, Atsushi Sugiyama, Yasue Sakaguchi, Yuji Nakamura, Keit ...

Session ID: O-33
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.70.0

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Effect of aging on QT interval in guinea pigs

Motohiro Shiotani, Takuma Harada, Junko Abe, Yoshimasa Hamada, Ikuo Ho ...

Session ID: O-34
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.71.0

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Evaluation of drug-induced QT prolongation in conscious telemetered common marmosets

Toshiko HARA, Sachiko SONE, Nobuyuki SHISHIDO, Shino KURAMOTO, Kohnosu ...

Session ID: O-35
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.72.0

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The evaluation of drug-induced blockage of hERG channel trafficking

Youko SASAKI, Makoto HIROYASU, Seiichi KATAYAMA, Mayumi OBO, Kentaro A ...

Session ID: O-36
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.73.0

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Investigation of culture conditions of rat cardiomyocytes for in vitro evaluation of cardiotoxicity 2-Analysis of Collagen gel+Matrigel culture-

Akifumi SHIODA, Tomoaki INOUE, Kazuko KOBAYASHI

Session ID: O-37
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.74.0

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Neurotoxicity of PFOS and PFOA

Itaru Sato, Yasuo Nishikawa, Norimitsu Saito, Yi-He Jin, Kazunori Ooam ...

Session ID: O-38
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.75.0

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Effects of Insulin-Sensitizing Agent on Autonomic Nervous Function in Zucker-Fatty Rats

Shuichi Towa, Wataru Toriumi, Masayoshi Kuwahara, Hirokazu Tubone

Session ID: O-39
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.76.0

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In vivo mutagenicity and oxidative DNA damage in the livers of gpt delta mice treated with flumequine

Yuichi Kuroiwa, Takashi Umemura, Kenichi Masumura, Keita Kanki, Yuji I ...

Session ID: O-40
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.77.0

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Detection and characterization of mitomycin C-induced gene mutations and micronucleus in the gpt delta L1 cell

AKIRA TAKEIRI, MASAYUKI MISHIMA, KENJI TANAKA, ASAKO HARADA, HIROHUMI ...

Session ID: O-41
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.78.0

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Relationship between the accumulation of p53 protein and the level of DNA damage induced by ENNG and mitomycin C in human hepatoma HepG2 cells

Syuji Nagasaki, Hisato Tanifuji, Shigeru Hisada

Session ID: O-42
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.79.0

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Genotoxic potential in vitro and liver initiation activity of ciprofloxacin

Tadashi ITOH, Yu F. SASAKI, Kiyomi KUMATANI, Hiroki SAKAI, Yoko KASHID ...

Session ID: O-43
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.80.0

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Difference between tamoxifen and toremifene in hepatocarcinogenic activity toward female rats: Study on the gene expression of hepatic proteins responsible for DNA repair and cell proliferation.

Masamichi HASHIBA, Toshihiko KASAHARA, Masakuni DEGAWA

Session ID: O-44
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.81.0

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Differences of Molecular Alteration between Radiation-Induced and N-Ethyl-N-Nitrosourea-Induced Thymic Lymphomas in B6C3F1 Mice

Shizuko Kakinuma, Mayumi Nishimura, Yoshiko Amasaki, Tatsuhiko Imaoka, ...

Session ID: O-45
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.82.0

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Expression of a system L-type amino acid transporter 1 in the rat Leydig cell tumor after prenatal exposure to di(n-butyl)phate

Tomoko Muto, Yoshikatsu Kanai, Shin Wakui, Hitoshi Endou

Session ID: O-46
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.83.0

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Analysis of MMP/TIMP activities in DMBA-induced rat mammary gland tumors

Kawai Koji, Koji Uetsuka, Hiroyuki Nakayama, Kunio Doi

Session ID: O-47
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.84.0

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Safety pharmacological follow-up study for assessing the QT interval prolongation -Carlsson's model in rabbits-

Hironobu Ikeda, Tomoko Nagao, Hirotada Tsutsumi, Ayahito Kimura, Isami ...

Session ID: O-48
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.85.0

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The investigation of in vivo micronucleus assay using flowcytometer

Masanori Kikuchi, Daisuke Mukai, Yukako Furuya, Sawako Shimada, Shoji ...

Session ID: O-49
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.86.0

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In vitro two-stage short-term assay for carcinogens

Noriho Tanaka, Makoto Umeda, Shin Asada, Hiroshi Ono

Session ID: O-50
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.87.0

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Skin sensitization test for risk assessment of metallic medical devices

Yukiko KANAZAWA, Hidetaka SATO, Chiaki MATSUOKA, Kohichi KOJIMA

Session ID: O-51
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.88.0

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Evaluation of developmental toxicity of UV stabilizer 2-(3,5-di-tert-butyl-2-hydroxyphenyl)-5-chlorobenzotriazole in rats

MAKOTO EMA, KATSUHIRO FUKUNISHI, MARIKO MATSUMOTO, AKIHIKO HIROSE, EII ...

Session ID: O-52
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.89.0

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DNA damage in mouse fetal liver and genital ridge cells induced by in utero exposure of DMN and MMS

Chiaki Tsukuba, Kazuei Matsubara, Jutarou Takahashi, Itaru Sato, Shuji ...

Session ID: O-53
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.90.0

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Effect on indole-3-acetic acid derivatives on neuroepithelium in rat embryos

Satoshi Furukawa, Koji Usuda, Masayoshi Abe, Izumi Ogawa

Session ID: O-54
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.91.0

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Evaluation of radiation-induced brain developmental effect by neuronal apoptosis in mouse fetus

Yuka Ishida, Yasushi Ohmachi, Takeshi Hiraoka, Shinji Fushiki, Yoshiya ...

Session ID: O-55
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.92.0

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Serum-free culture of murine embryonic stem (ES) cells for the analysis of developmental toxicity

ATSUYA TAKAGI, JUN KANNO

Session ID: O-56
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.93.0

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Changes of sperm functions and epididymal gene expression in the rats treated with sulfasalazine for several days

Tamio Fukushima, Yoshimasa Hamada, Masatoshi Komiyama, Chisato Mori, I ...

Session ID: O-57
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.94.0

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Granulosa cell is type II apoptosis-cell and regulates follicular atresia in mammalian ovaries

Noboru Manabe, Fuko Minehata, Yasufumi Goto, Naoko Inoue, Akihisa Maed ...

Session ID: O-58
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.95.0

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Effects of heavy metal exposure on the phosphorylation of p53 protein

Masato Matsuoka

Session ID: O-59
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.96.0

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Effect of metallothionein on cadmium accumulation in fetus

Akiko Honda, Masahiko Satoh, Tatsuya Hasegawa, Yoshiyuki Seko, Junko S ...

Session ID: O-60
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.97.0

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Effects of methylmercury on the intracellular trafficking in Saccharomyces cerevisiae

Yasutaka Murai, Gi-wook Hwang, Akira Naganuma

Session ID: O-61
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.98.0

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Glutathione-S-transferase and dialdehyde reductase activities toward aflatoxin B1 in livers of experimental and farm animals

Phitsanu Tulayakul, Shohei Sakuda, Ke-Su Dong, SUSUMU KUMAGAI

Session ID: O-62
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.99.0

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In order to gain a better understanding of the relative activities of glutathione S-transferase (GST) and aldehyde reductase toward aflatoxin B1 (AFB1) in relation to the variation of species susceptibilities, we studied the in vitro cytosolic GST and reductase activities in liver tissues from male Fischer rats, ICR mice and golden hamsters, adult male rainbow trouts and female piglets. The GST activity was determined by incubating the liver cytosol with glutathione (GSH) and AFB1 in the presence of the hamster liver microsomes to generate AFB1-8, 9-epoxide from AFB1. The reaction product, AFB1-GSH conjugate was quantified by HPLC with pirkele-concept chiral column using AFB1-GSH conjugate prepared by chemical reaction as standard. The reductase activity was determined by incubating liver cytosol with AFB1-dialdehyde, followed by the quantification of the metabolic product, AFB1-dialcohol, by HPLC. AFB1-dialcohol for HPLC was prepared by chemical reaction of AFB1-epoxide and N,N dimethylformamide standard. All the animal species possesed the GST activities and AFB1-GSH formed was increased with AFB1 concentration according to first order enzyme kinetics reaction. The Vmax and Km values of the GST activities in rodent species were higher and lower, respectively, than those in the trout and pig, being consistent with the relative susceptibilities to AFB1 of these animal species. However, no relationship was noted between the reductase activity and species susceptibility. Thus, the result of this study shows that GST toward AFB1, but not aldehyde reductase, is a determinant of the variation of species susceptibilities to AFB1.

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Functional analysis of 14-3-3beta gene overexpressed in aflatoxin B₁-induced rat hepatoma cells

Yasushi Kawasaki, Akinori Sugiyama, Yuuko Komiya, Nobuya Kurabe, Fumio ...

Session ID: O-63
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.100.0

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Hepatotoxicity of T-2 toxin in mice

Satoko Miwa, Junko Shinozuka, Naoko Murakami, Chinami Aruga, Hisako Fu ...

Session ID: O-64
Published: 2005
Released on J-STAGE: June 08, 2005

DOIhttps://doi.org/10.14869/toxp.32.0.101.0

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