Annual Meeting of the Japanese Society of Toxicology

Annual Meeting of the Japanese Society of Toxicology

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The 42nd Annual Meeting of the Japanese Society of Toxicology

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Symposium 8

Nano-safety science for sustainable nanotechnology

Yasuo YOSHIOKA, Kazuma HIGASHISAKA, Yasuo TSUTSUMI

Session ID: S8-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S8-3

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The effects of exposure to environmental chemicals in lifestyle diseases

Rie YANAGISAWA

Session ID: S8-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S8-4

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Cellular and molecular mechanism of the aggravation of modern diseases by the environmental pollutants

Eiko KOIKE

Session ID: S8-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S8-5

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Symposium 9

Drug oxidation activities in experimental animals and humans

Hiroshi YAMAZAKI, Yasuhiro UNO

Session ID: S9-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-1

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Analysis of cytochromes P450 and UDP-glucuronosyltransferases in cynomolgus monkeys

Yasuhiro UNO, Hiroshi YAMAZAKI

Session ID: S9-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-2

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Drug metabolism Phase II enzymes -The novel way of identification of species differences-

Yoshinori IKENAKA, Aksorn SAENGTIENCHAI, Mayu KAKEHI, Wageh Sobhy DARW ...

Session ID: S9-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-3

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Development of xenobiotic metabolizing enzymes expressing yeast for analysis of xenobiotic species differences

Shinichi IKUSHIRO, Miyu NISHIKAWA, Toshiyuki SAKAKI

Session ID: S9-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-4

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Regulation and metabolic property of cytochrome P450 in fish

Akira KUBOTA, John J STEGEMAN

Session ID: S9-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-5

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Molecular mechanisms involved in the susceptibility to chemical substances in birds

Hisato IWATA, Masashi HIRANO, Eun-Young KIM

Session ID: S9-6
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S9-6

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Symposium 10

Nonclinical and clinical inter-disciplinary crosstalk toward mechanism based safety strategy - View point of toxicological sciences

Koichi UENO

Session ID: S10-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-1

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Scientific evaluation of drug safety through a clinical and non-clinical interaction

Masaru IWASAKI

Session ID: S10-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-2

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Translational safety biomarkers of toxicity and disease using cutting edge systems biology approaches

Donna L. MENDRICK

Session ID: S10-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-3

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Expanded efforts in drug discovery have not resulted in a parallel increase in the number of safe marketed drugs. Drug-induced cardiotoxicity and hepatotoxicity continue to be major hurdles requiring new methods to identify unsafe compounds earlier in the pipeline and to better manage patient care. A systems biology approach using genomics, metabolomics, proteomics, epigenomics and bioinformatics coupled with in vitro and in vivo methods is beginning to make progress that might improve compound selection and empower personalized (precision) medicine. Examples to be presented include translational work being done in doxorubicin-mediated cardiomyopathy and acetaminophen (paracetamol) induced hepatotoxicity in rodents and humans.

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Exploration and validation of safety biomarkers using clinical samples

Yoshiro SAITO, Keiko MAEKAWA, Kosuke SAITO, Ryosuke NAKAMURA, Yuji KUM ...

Session ID: S10-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-4

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Practical use of PK/PD for drug risk evaluation -propositions at clinical site-

Toshiaki NAKAMURA

Session ID: S10-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-5

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Pharmacokinetics-based safety translation: How do we discriminate significant risks?

Akihiro HISAKA

Session ID: S10-6
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-6

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Risk minimization strategy - What can we do? -

Pascal YOSHIDA, Shinji YOKOYAMA, Yasuto NAKATA, Jun YAMANAKA, Hiroki N ...

Session ID: S10-7
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-7

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Scientific approach to the risks of adverse drug reactions in the interdisciplinary field of nonclinical and clinical safety - Needs of crosstalk communication from the stand-point of nonclinical safety

Ichiro NAESHIRO

Session ID: S10-8
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S10-8

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Symposium 11

Reactive cysteine persulfide-dependent protein translation: Protein S-polythiolation involving redox signaling

Takaaki AKAIKE

Session ID: S11-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S11-1

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Mechanism of methylmercury-induced neurotoxicity by disruption of reactive sulfur species-regulated redox signaling

Hideshi IHARA

Session ID: S11-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S11-2

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Protective roles of cystathionine γ-lyase, the cysteine/reactive sulfur species-producing enzyme, against acetaminophen-induced hepatic injury

Isao ISHII, Yumi ABIKO, Shotaro KAMATA, Yoshito KUMAGAI

Session ID: S11-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S11-3

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The phase zero reaction: Reactive sulfur species responsible for inactivation of electrophiles

Yoshito KUMAGAI

Session ID: S11-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S11-4

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Symposium 12

Disturbance of nursing behaviors and the growth of the offspring by maternal exposure to dioxin

Tomoki TAKEDA, Misaki FUJII, Waka IZUMOTO, Yukiko HATTORI, Hideyuki YA ...

Session ID: S12-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S12-1

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Roles of cPLA₂α and AhR in the manifestation of dioxin toxicity

Nozomi FUJISAWA, Wataru YOSHIOKA, Chiharu TOHYAMA

Session ID: S12-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S12-2

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Perinatal exposure to low-dose methylmercury induces dysfunction of motor coordination with decrease in synaptophysin expression in the cerebellar granule cells of rats

Masatake FUJIMURA, Jinping CHENG, Wenchang ZHAO

Session ID: S12-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S12-3

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Effects of nanoparticle exposure on the brain development - predictive markers and their toxicological implications

Masakazu UMEZAWA, Atsuto ONODA, Shotaro KAWAZOE, Ken TACHIBANA, Ken TA ...

Session ID: S12-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S12-4

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Association of prenatal exposure to persistent organic pollutants with birth weight and child development

Miyuki IWAI-SHIMADA, Nozomi TATSUTA, Naoyuki KUROKAWA, Kunihiko NAKAI, ...

Session ID: S12-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S12-5

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Symposium 13

Outline and history of GLP regulation on pathological peer review

Yuji OISHI, Munehiro TERANISHI, Katsuhiko YOSHIZAWA, Hiroshi ONODERA

Session ID: S13-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S13-1

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OECD pathology peer review guidance

Munehiro TERANISHI, Yuji OISHI, Katsuhiko YOSHIZAWA, Hiroshi ONODERA

Session ID: S13-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S13-2

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Opinions and views of international societies of toxicologic pathology

Katsuhiko YOSHIZAWA, Munehiro TERANISHI, Yuji OISHI, Hiroshi ONODERA

Session ID: S13-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S13-3

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Symposium 14

Off-target search with large-scale virtual screening data

Ryo KUNIMOTO

Session ID: S14-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S14-1

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Prediction of HLA-associated IDT

Noriaki HIRAYAMA

Session ID: S14-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S14-2

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Predicting hepatotoxic potential of new drug candidates in patients using DILIsym

Brett A. HOWELL

Session ID: S14-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S14-3

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A mechanistic, multi-scale, mathematical model is being developed through the DILI-sim Initiative to assist in the safety characterization of compounds in clinical development. The model is made available in the form of DILIsym^® software. The primary goals for DILIsym^®include understanding how in vitro toxicity assay results translate to in vivo scenarios, the relevance of pre-clinical results for humans, and how biomarker results translate to patient safety. The primary mechanistic areas of focus within the model include reactive oxygen/nitrogen species, mitochondrial dysfunction, steatosis (lipotoxicity), innate immunity, and bile acid homeostasis and disruption. Case studies will be presented demonstrating how drug metabolism and disposition intersect with hepatotoxicity, and how utilizing mechanistic modeling approaches incorporating this information allows for a better understanding of safety risks. Key areas of focus will include clinical trial optimization, novel biomarkers and their relevance in the clinical trial setting, and the use of modeling and simulation methods to provide context for biomarker signatures that are difficult to interpret.

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Assessment of drug-induced arrhythmogenic risk using the heart simulator

Jun-ichi OKADA, Takashi YOSHINAGA, Junko KUROKAWA, Takumi WASHIO, Hiro ...

Session ID: S14-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S14-4

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Classification and characterization of side effects based on FDA spontaneous reports of drug adverse events

Sayaka MIZUTANI, Masaaki KOTERA, Susumu GOTO

Session ID: S14-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S14-5

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Symposium 15

Keap1-Nrf2 system: a multiple sensor for responding to a wide variety of chemical compounds and environmental stress

Makoto KOBAYASHI

Session ID: S15-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S15-1

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Characterization of protein phosphorylation signaling in the context of comparative genomics

Hisayoshi YOSHIZAKI, Shujiro OKUDA, Toshiya HAYANO

Session ID: S15-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S15-2

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Activation of redox signal transduction pathways mediated by environmental electrophiles through covalent modification

Yoshito KUMAGAI

Session ID: S15-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S15-3

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Two modes of action with organotin-induced immunosuppression via nuclear receptor signaling

Tsuyoshi NAKANISHI

Session ID: S15-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S15-4

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Protective response of cells to ER-stress: Difference of autophagy- and apoptosis-inducing mechanisms

Saburo MATSUO, Hiroshi NAKAGAWA, Kazuhiko NISHIMURA

Session ID: S15-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S15-5

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Symposium 16

Garuda platform as a basis for systems toxicology

Hiroaki KITANO

Session ID: S16-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S16-1

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Percellome toxicogemics approach to catalog the dynamic biomarkers for toxicity prediction

Jun KANNO, Ken-ichi AISAKI, Satoshi KITAJIMA

Session ID: S16-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S16-2

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Drug discovery from transcriptome to overcome incurable diseases

Masatoshi HAGIWARA

Session ID: S16-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S16-3

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Signatures of mutational processes in human cancer

Hiroyuki ABURATANI

Session ID: S16-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S16-4

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Symposium 17

Current status and perspectives of pediatric drug development

Katsuhiko ICHIMARU

Session ID: S17-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-1

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Translational research on bone growth in mature and juvenile animals and adult and young humans

Naoto HORAI, Takashi YAMAMOTO, Akihiro ARIMA, Mutsumi SUZUKI

Session ID: S17-2
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-2

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Basic knowledge of physiology of reproduction in toxicological evaluation of juvenile animals

Mariko SHIROTA, Midori YOSHIDA

Session ID: S17-3
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-3

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Juvenile animal studies for pediatric drugs on marketing approval reviews

Takuya NISHIMURA

Session ID: S17-4
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-4

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Future direction and issues of ICH S11

Mutsumi SUZUKI

Session ID: S17-5
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-5

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Current status of pediatric drug development in Japan

Hidefumi NAKAMURA

Session ID: S17-6
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S17-6

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Symposium 18

Oxidative DNA damage and intestinal cancer

Teruhisa TSUZUKI

Session ID: S18-1
Published: 2015
Released on J-STAGE: August 03, 2015

DOIhttps://doi.org/10.14869/toxpt.42.1.0_S18-1

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