Nitroxyl radicals are used as probes for ROS measurement by ESR. Therefore, it is important to select appropriate probes and modifications for the evaluation of the relationship between oxidative stress and various diseases. This review introduces a study on the pharmacokinetics of probes, in vivo redox evaluation of sepsis model mice using acyl-protected probes, and an examination of the photosensitivity mechanism.
When the author graduated from university, her aim was to become a pharmacist capable of recommending prescription medicines to doctors and teaching others to do the same. To achieve this goal, she developed comprehensive curricula incorporating progressive educational tools such as PBL and SGD. the effectiveness of these tools and curricula was evaluated. Many evidence on the most effective ways to recommend prescription medicines to doctors was gradually established. This review describes the author's research over 43 years.
This comprehensive review discusses the dynamic structural changes of tannins in living plants or food processing based on the author's 40 years of research. The discovery of common reaction mechanisms in ellagitannin biosynthesis and black tea polyphenol formation, in addition to the structural determination of new metabolites, holds significance in the fields of phytochemistry and food chemistry. The research findings outlined in this review provide valuable insights into understanding the significance of tannins.
This review article contains application of hydrogenated lecithin as additives. When preparing solid dispersions using phosphatidylcoline (PC) as a carrier, drug with hydrogen-donating groups interacts with PC to produce amorphous solid dispersions with high drug content; this overcomes improves drug absorption. The drug was solubilized and supersaturated in the oil-based gel formed with hydrogenated lecithin; this facilitates drug permeation through the skin. The effects of various oils on skin permeation of drugs are also addressed.
This review article describes inhibitors of enzymes involved in the epigenetic processes, e.g., DNA methyltransferases and histone deacetylases, increase expression of drug metabolizing cytochrome P-450s (CYPs) 1B1 and 3A4.It also describes alteration of gene regulation of CYP1 family enzymes through aryl hydrocarbon receptors in three dimensional cultures of human solid cancer cells. As changes in gene expression by epigenetic inhibitors accompany increased cancer drug sensitivities, relationship between cellular drug sensitivities and cell environments seems worth to be investigated.
This narrative review comprehensively clarified the current status and issues of scientific evidence for functionality in the Foods with Function Claims system based on previous research. Systematic reviews and randomized controlled trials (RCTs) in notification often have low-quality notifications. Therefore, the author reports that it is necessary to correctly communicate this information to consumers in order to make appropriate purchasing decisions.
With the change in the qualifications for the national pharmacist
examination, the education in the pharmaceutical department is currently
undergoing a major turning point. These articles are presented a summary of
nine of the speakers at a symposium entitled ” Where is the education in pharmaceutical sciences headed for the
development of new human resources in the 21st century?” All of the papers
will be helpful for the direction of pharmacy education in the future.
This review describes aging studies employing in vitro animal cell cultures, on which the author has been working for more than 40 years after pharmacist education and then cell biology researches. The author started observation and comparison as the cell undergoes aging, proceeded to analysis of cell surface components, and discovered novel adaptor proteins and intracellular signaling for the control of senescence. The presentation here would be appropriate introduction to the cellular aging for researchers with pharmaceutical or biological interest.
Barley tea (Mugicha) is recognized as a reliable alternative to drinking water even for infants and elderly individuals to quench thirst and maintain hydration throughout the year. This author investigated the application of barley tea as a functional food, and found novel anti-thrombotic effects using fibrin plate method. In this study, Mugicha extract and its simulated digestate exhibited the fibrinolysis enhancing activity in vitro. The results of this study suggest the potential use of barley extract as a functional food.
This is the first report of myositis caused by gefitinib. Myositis has been reported with only osimertinib among epidermal growth factor receptor tyrosine kinase inhibitors. In this report, the detailed course of gefitinib-induced myositis, including changes in creatine kinase levels was described. In addition, this case was compared with the case of osimertinib previously reported regarding the timing and severity of onset. This report is helpful for gefitinib treatment.
The author, a natural product chemist and prolific author, has conducted significant phytochemical research and the discovery of new antibiotics. His classification of naturally occurring alkaloids into 16 categories according to their biosynthetic pathways is a highly significant achievement. He has written many books related to poisons and medicines, and disclosed the fundamental relationship between "Taketori-Monogatari" and "Shosoin-Drugs (poisons)" through extensive literature research. Cumulatively, these are extremely profound research and scholarly contributions to science and society.
There are many lectures for the regional community residents as with the aim of promoting appreciate use of medications. The authors’ activity is characterized as consisting of combined lectures and practices by pharmacists. This activity indicated that it improved the basic medicine-related knowledge of the regional community residents among a wide range of age groups. The authors’ activity leads to the development of regional community activity, by the coming together of the regional community residents of various age.
Chemical bonds are drawn as lines connecting atoms to atoms. Even chemical bonds represented by uniform lines have various properties depending on the arrangement of the surrounding atoms. When the lines are formed by nitrogen atoms, several characteristic chemical bonds were observed. The nature of these characteristic chemical bonds depends on the overall structure of the molecule. This review also explains how new chemical bonds have led to the creation of new functions, such as biological activity.
This study developed a practice model of pharmacists in pediatric homecare medicine by the data analyzed using the M-GTA. This analysis generated 8 categories and 21 concepts, including the two concepts of “optimization of prescription and device selection to enable the hospital-to-home transition” and “optimization of prescription and device selection for ensuring patient safety” form the core of clinical decision making in the pharmacotherapy management process. These results could be helpful in the education of pharmacists in pediatric homecare medicine.
Multiple good manufacturing practice (GMP) incompliance and inappropriate quality cases of generic pharmaceuticals surfaced from 2020 led to a serious and long-term shortage of the products at medical institutions in Japan. This review overviewed the causes of drug shortages and introduced measures taken by marketing/manufacturing authorization holders (MAH), industry groups, and governments to improve manufacturing management. Inadequate formulation and process design at the time of development as a possible root cause was also discussed.
Sandhoff disease (SD) is a glycosphingolipid storage disease resulting from a genetic mutation in HEXB and associated deficiency in β-hexosaminidase activity. To examine abnormal neuronal lineage differentiation and development during the asymptomatic phase of SD, authors used iPS cells derived from Hexb-knockout mice (SD-iPSCs). Differentiation ability along the time axis appears to be altered in SD-iPSCs, in which neural stem cells acquire late developmental properties at an early stage. Their findings provide new insights into the complex pathogenesis of SD.
Green tea components, such as catechins are reported to have anti- viral/bacterial and anti-inflammatory effects in experimental studies. This review demonstrated the clinical significance of green tea focusing on the respiratory tract infections based on their clinical studies. Consuming or gargling green tea or its components significantly aided in the prevention of influenza. Catechin inhalation also decreased the bacterial load of methicillin-resistant Staphylococcus aureus. Although the clinical evidence remains limited, further studies are expected to clarify the clinical efficacy.
The need for ensuring the traceability of pharmaceutical products from shipment to patient distribution is growing with the spread of falsified medicine and poor medication adherence. The microtaggant technologies that can encode individual numbers on pharmaceutical products has gained much attention to solve these problems. The author well organized the advantages and disadvantages of each encoding method of the microtaggants. This review is useful to understand the emerging traceability system.
Biased agonists of GPCRs are agonists that selectively induce G protein- or β-arrestin-mediated responses. Biased agonists have become an important concept in drug discovery, as they are thought to result in drugs with fewer side effects. It should be noted, however, that the actions of G protein biased agonists can also be explained by the effects of partial agonists. In many cases, biased agonists bind to and exert their effects at different sites than endogenous agonists.
Bioactive compounds from plant (phytochemicals) play an important role as seed compounds for prevention and treatment of many diseases. Recently, the author isolated a novel topoisomerase II inhibitor named erypoegin K, an isoflavone from Erythrina poeppigiana, which showed enantio-selective potent apoptosis-inducing activity towards various types of cancer cells. This review mainly describes studies on erypoegin K. It also includes other phytochemicals with apoptosis-inducing and anti-inflammatory activities. This review is useful for researchers developing new anticancer and anti-inflammatory drugs.