Biased agonists of GPCRs are agonists that selectively induce G protein- or β-arrestin-mediated responses. Biased agonists have become an important concept in drug discovery, as they are thought to result in drugs with fewer side effects. It should be noted, however, that the actions of G protein biased agonists can also be explained by the effects of partial agonists. In many cases, biased agonists bind to and exert their effects at different sites than endogenous agonists.
Development of Drug Delivery System by Utilizing Absorption from Liver Surface and Its Application
Released on J-STAGE: August 01, 2009 | Volume 129 Issue 8 Pages 925-932
What Is Qualitative Research?
Released on J-STAGE: June 01, 2017 | Volume 137 Issue 6 Pages 653-658
Food Poisoning by Ginkgo Seeds through Vitamin B6 Depletion
Released on J-STAGE: January 01, 2019 | Volume 139 Issue 1 Pages 1-6
Examination of Factors Affecting Adverse Reactions and Dosage Reduction in UGT1A1 Genotyped Patients: A Retrospective Survey of Irinotecan
Released on J-STAGE: February 01, 2012 | Volume 132 Issue 2 Pages 231-236
Keinosuke Okazaki, Toru Watanabe, Isao Saito, Jun-Ichiro Murayama
Chronic Effects on Kidney Function by “Triple Whammy” (Combination of Renin and Angiotensin Type Inhibitor, Diuretic Drug and Nonsteroidal Anti-inflammatory Drug)
Released on J-STAGE: November 01, 2019 | Volume 139 Issue 11 Pages 1457-1462
Yuki Kunitsu, Tetsuichiro Isono, Daiki Hira, Tomohiro Terada