The modification of polyethylene glycol (PEG), i.e. PEGylation is commonly used approach for increasing stability of drug delivery systems (DDSs), but results in loss of activity simultaneously. This article describes the trade-off relationship between activity and stability as PEG dilemma and strategies to overcome PEG dilemma. The authors developed a cleavable PEG lipid in response to tumor microenvironment, a pH-sensitive fusogenic peptide, and pH-sensitive cationic lipids in response to endosome/lysosome, which balanced activity and stability of DDSs and exerted therapeutic effect of nucleic acid cargos.
Collaborative Approach to Heart Failure Care
Released: August 01, 2016 | Volume 136 Issue 8 Pages 1115-1116
Hiroyuki Takano, Yukihito Sato
What Is Qualitative Research?
Released: June 01, 2017 | Volume 137 Issue 6 Pages 653-658
Furanocoumarins Contents and Cytochrome P450 3A (CYP3A) Inhibitory Activities of Various Processed Fruit Peel Products: Outflow of 6′,7′-Dihydroxybergamottin during Processing Treatment of Peel
Released: May 01, 2011 | Volume 131 Issue 5 Pages 679-684
Masaru ISHIHARA, Hikaru TODA, Nobuyoshi SUNAGANE, Takafumi OHTA
Evaluation of Antibiotics for the Treatment of Bacteremia Due to Extended-spectrum β-Lactamase-producing Escherichia coli
Released: June 01, 2015 | Volume 135 Issue 6 Pages 829-833
Takafumi Sugawara, Noritaka Murakami, Nobue Uetake, Kouichi Hiraki
Examination of Factors Affecting Adverse Reactions and Dosage Reduction in UGT1A1 Genotyped Patients: A Retrospective Survey of Irinotecan
Released: February 01, 2012 | Volume 132 Issue 2 Pages 231-236
Keinosuke Okazaki, Toru Watanabe, Isao Saito, Jun-Ichiro Murayama