MTF-1 is a transcription factor activated in response to an increase in concentration of intracellular free zinc. In this article, MTF-1 is reviewed from its discovery to unique characteristics as an intracellular zinc sensor, mainly based on the author’s research results. It is indicated that clarification of the zinc signaling system mediated by MTF-1, together with the analysis of the genes under its control, is useful for unraveling novel biological roles of essential zinc.
What Is Qualitative Research?
Released: June 01, 2017 | Volume 137 Issue 6 Pages 653-658
Nanosize Particle Analysis by Dynamic Light Scattering (DLS)
Released: February 01, 2019 | Volume 139 Issue 2 Pages 237-248
Mechanism of Cell Proliferation—Cell Cycle, Oncogenes, and Senescence
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Do Myokines Have Potential as Exercise Mimetics?
Released: October 01, 2018 | Volume 138 Issue 10 Pages 1285-1290
Research Misconduct in Japan and How It Is Covered by the Media
Released: April 01, 2018 | Volume 138 Issue 4 Pages 459-464