The purpose of this retrospective study was to evaluate predictive factors associated with local response of hepatocellular carcinoma (HCC) after transarterial chemoembolization with drug-eluting beads (DEB-TACE). A total of 123 HCC patients without intrahepatic metastases underwent DEB-TACE (50-100 μm superabsorbent polymer microspheres, 1 mg epirubicin/mg microsphere), and 338 nodules measuring ≥1 cm in longest diameter were selected as target lesions for nodule-based analysis. Local tumor response was evaluated 3 months after initial DEB-TACE according to the modified RECIST criteria. Univariate analysis showed that longest diameter of ≥3 cm, peripheral location, selective embolization, DEB dose of ≥10 mg, and no previous conventional TACE were factors significantly associated with better response. On multivariate analysis, longest diameter of ≥3 cm (odds ratio [OR]: 2.8; P = 0.001), peripheral location (OR: 2.1; P = 0.008), selective embolization (OR: 2.2; P = 0.003) and DEB dose of ≥10 mg (OR: 2.1; P = 0.006) remained significant predictive factors. All nodules were divided into three groups according to longest diameter (1-2 cm [n=125], 2-3 cm [n=97], and ≥3 cm [n=116]). Response rates were 44.8％, 67.0％, and 82.8％ in the 1-2 cm, 2-3 cm, and ≥3 cm groups, respectively. A longest diameter of ≥3 cm, peripheral location, and selective embolization using a sufficient dose of DEB were significant predictors of response after DEB-TACE.

抄録全体を表示