An electron microscopic study was performed on the developmental process of the Mukai strain of Japanese encephalitis virus propagated in vitro PS cells.
On the basis of electron microscopic observation, it is suggested that the virus particles develop by “budding” from the membrane of the cytoplasmic vacuole. The particles then collect in the vacuole, usually in random arrangement, but occationally in cystalline arrays. The virus-containing vacuole migrates to the cell surface and liberates the virus particles from the cell.
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