In September, 1958, a blood sample was referred to us for Rh-typing. The patient had nine pregnancies, each one of which ended in a miscarriage at the third to seventh month. She belonged to the blood group A, and the Rh
0 (D) factor was positive. Her serum agglutinated all the red cells used in the test (except her own cells) both at 37C and at low temperatures. In the presence of complement, hemolysis was observed at 37°C against random test cells.
Further investigations revealed that her red cell was Tj (a-), and the agglutinin in question appeared to be independent of ABO, MNS or Rh system. Therefore, the authors concluded that her serum contained Tj
a antibody. Our diagnosis was later confirmed by Drs. P. Levine, R. Sanger and I. Dunsford.
Since the discovery of Tj
a antibody by Levine et al., in 1951, this antibody has been demonstrated only in 16 individuals of 10 families throughout the world, so that the authors have discovered the eleventh family of Tj
a antibody. None of the members of this family, except the patient herself, was found to be Tj (a-).
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