1) Total protein in normal rat serum shows a marked increase along with growth until the 4th week after birth, followed by a slight decrease at the 6th week and subsequently by a gradual increase until the 14th week. Females showed slightly higher values than males. Albumin and total protein showed approximately similar fluctnations. Scarcely any changes in α-globulin were seen according to the age in weeks. β-globulin markedly increased until the 4th week after birth, followed by a gradual decrease by the 8th week and further by a gradual increase until the 10th week. γ-globulin increased until the second week after birth followed by a gradual decrease by the 5th week, and further by a gradual increase until the 10th week.
2) Rats with chloroma showed a decrease in total protein and albumin, an increase in α₂-globulin, and a decrease in β-globulin and γ-globulin in serum.
3) The rate of transference of rat chloroma decreased with advancing age, being probably related with the ability of production of immunoglobulin in vivo.
4) In serum of rats resisting the transference of chloroma, γ-globulin was increased to twice the normal level.
5) The protein fractions of serum of rat with chloroma and rat resisting transference of chloroma probably reflect active pattern based on active reaction of the living organism against the tumor.

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