The results in 53 cases of lung canser endoscopically treated by HpD and argon dye laser photoradiation were examined to evaluate the effectiveness and delineate the limitations of this new method in lung cancer cases.
The Sex distribution was 48 males and 5 females. The age distribution was 38 to 78. The cases were clinically clasified as 8 early stage, 4 stage 1,9 stage II, 22 stage III and 10 stageIV. Histologically 38 were squamous cell carcinoma,7 adenocarcinoma, 4 large cell carcinoma, 3small cell carcinoma and 1 bronchial metastasis of malignant melanoma. 2.0-5.0mg/kg body weight of HpD was administered intravenously 48-72 hours prior to photoradiation. The surfase of the lesion was irradiated in cases of superficial invation and in cases of polypoid tumors intratumoral photoradiation was performed via a quartz fiber inserted through the fiberoptic bronchoscope. Therapeutic effectiveness was evaluated as follows; complete remission(CR) means no evidence of tumor by fiberoptic bronchoscopy, biopsied histology and brushing cytology, significant remission (SR) means more than 60% reduction of the lesion endoscopically, partial remition (PR) means 20-59% reduction endscopically and no remission (NR) means less than 20% reduction. CR was obtained in 7 out of 8 eary stage and lout of 4 stage 1. SR. was obtained 5 out of 41 advanced cases. Opening of bronchi obstructed by tumor was obtained in 21 out of 38 foci. From these results this therapy was shown to be effective to treat eary stage superficial lung cancer curatively.
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