We have been investigating novel antimycotics as well as substances indicated synergistic effects of antimicrobial activities with addition of small amount of recently-developed imidazole antimycotics shown in Fig. 1. This time, we isolated
Pericillium sp. No.Y-11930 which yielded a physiologically active substance. The substance was obtained as pillar-shaped crystals and showed 30-125-fold strong synergistic effects against
Candida sp. with addition of econazole 1), miconazole 2) and clotrimazole 3). The substance was hereinafter called as synergisidin in relation to this synergism. Synergisidin showed C
16H
24O
4 (MW: 280.2552), [α]
10D+106.23° (
c 0.33, MeOH) and mp. 200°C and identical with brefeldin A and ascotoxin (decumbin) from physicochemical properties and comparison with them.
This paper deals with production, extraction, purification, biological properties and physicochemical properties of synergisidin.
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