Effects of trimebutine maleate (TM-906) on gastrointestinal motor activity of interdigestive state were studied in seven unanaesthetized dogs by means of chroni-cally implanted force transducers.
In animals which showed typical interdigestive motor pattern consisted of long lasting motor quiescence and recurring high-amplitude contractions (interdigestive contractions), intravenous infusion of TM-906 (0.6-6.0mg/kg-hr) shortened the quiescent period. During TM-906 infusion, the number and the duration of the interdigestive contractions decreased in the gastric antrum. These effects were in a dose dependent manner. Infusion of TM-906 of 6.0mg/kg-hr over 60min introduced additional responses: persistent contractions different from the usual interdigestive contractions and delayed onset of the interdigestive contractions. Metoclopramide (1.8-6.0mg/kg-hr) developed high-frequency contractions with gradually increasing amplitude and caused enhancement of the interdigestive contractions.
In three animals which showed anomalous fasted motor pattern consisted of continuous low-amplitude contractions, bolus i.v. injection of TM-906 (2.0-2.5mg/kg) introduced a transient suppression of the contractions in the antrum. Metoclopramide (1.0mg/kg i.v.) potentiated and hyoscine-N-butylbromide (0.1mg/kg i.v.) inhibited the contractions in all the regions.

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モノづくりの現場は，先端技術の高度化，複雑化でプロセスが複雑化・多様化となり，関与する人々の範囲も拡がっている．時として，品質作り込みの力量がそれらの変化に追従せず，仕様の不整合に繋がることがある．現状何が問題かを早く捉えて気付き，問題を解決することにある． 本稿で紹介するg-VTA は，プロセスに業務フローというフィールドを用い，漏れなく潜在化問題を収集し，顕在化して「問題の見える化」による情報の共有化を図る． g-VTA は，現場でその適用性を確認し，業務品質の確保とモノづくりの深層競争力とを捉えるための自工程完結に向けた有効な支援ツールになることが既に実証されている．

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