1. In the present experiment, diethyl-paranitrophenyl-thiophosphate in emulsion was administered subcutaneously on rats twice per week in different doses of 24mg, 16mg, 8mg, 4mg and 2mg/kg. Then, histophathological investigations were made on the changes produced in the heart dividing the animals into three groups of acute, subacute and chronic stages by the length of their survival days.
2. In the acute stage, histologically, the granular degeneration of cardiac fibers was strong in the group administered of large doses and vice versa being nearly parallel to the amount administered, while vacuolar degeneration, swelling, homogenization, colliquative degeneration etc were strong in the groups received the administration of medium doses and mild in the groups of small doses without demonstrating parallel relationship between these changes and the amount administered.
3. In the subacute stage, all the changes like granular degeneration, swelling, vacuolar degeneration and colliquative changes nearly parallelled the amount administered except homogenization which was stronger in the groups received medium doses without demonstrating parallel relationship to the amount administered.
4. In the chronic stage, granular degeneration, vacuolar degeneration, colliquative degeneration etc were recognized only in the groups admistered of small doses demonstrating parallel relationship to the amount administered.
5. It was proved that on administration of Parathion over a prolonged period of time, the changes caused on the cardiac fibers by metabolic disturbances are characterized by the atrophy and homogenization of cardiac fibers, and in the interstitium, infiltration of round cells, proliferation of fibroblasts and argentaffine fibers, and calcification, and thus advance into fibrosis accompanied by tissue reactive reparation.

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Embryonal adenosarcom which is called as embryonal mixed tumor of kidney, Wilms's tumor etc. was first reported by Eberth in 1872. Reports on this tumor were published, thereafter, by Birsch-Hirschf eld, Lubarsch and numerous other investigators. Its occurrence in Japan, however, has been quite rare.
1. The authors could investigate an embryonal adenosarcoma formed on the left side kidney of a male infant of 3 years and 10 months old.
2. After extirpation of the adenosarcoma, the patient followed a favorable clinical course and discharged from the hospital 2 weeks after operation.
3. On histological examination, the adenosarcoma was found to be the one classifiable as Masson's type 3 (nephrogenic dysembryoma) .

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In the present experiment, female rats received subcutaneous injections of diethyl-paraniro-phenyl-thiophosphate (Parathion) in a dose of 2, 4, 8, 12, 16 mg/kg twice per week over a prolonged period of time and the influence of this injection on the mother rats and new borns (on the 1st, 3rs and 7th day) was investigated by pathomorphological survery with a special ref ence on the skeletal muscles.
As for the new born rats, lesions produced are divided into two kinds of the growth disturbance and the regressive changes. Namely, on the 1st day, changes are characterized by the growth disturbance, on the 3rd day, regressive changes become predominant under the modification of the growth disturbance. While on the 7th day, there is a morphological manifestation of the weakening of regressive changes. Changes observed on the 3rd day, however, are the severest.
On the other hand, changes of the mother rats are characterized by the circulatory disturbance, namely, vascular dilatation, hyperemia and congestion, swelling, increase in the vascular permeability due to degeneration, infiltration of round cells and deposition of edematous exudate in the perivascular interstitium, reparative reactions against the said tissue destructive changes and, moreover, the production of lattice fibers and argyrophilic fibers in the interstium as a process for organization advancing further into the hardening of the lesions through the replacement of muscular tissues by the connective tissue fibers.
It is considered, further, that aside from the toxicity of Parathion, namely, the disturbance caused by CHE, the inhibition of oxydoreductase system together with the hypoxydose due to the administration of Parathion are influencing on the mother rats as well as their embryos via placentally through the porpetual exposure in the maternal body producing the changes described herein.

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1. An investigation was made on 9 cases of neuroblastoma from 4 months to 60 years old.
2. Out of the 9 cases of neuroblastoma, 5 were females and 4 were males.
3. Histopathologically, neuroblastoma was classified into 3 types of small round cell type (I), polar cell type (II) and nerve cell type (III) .
4. Out of the 9 cases investigated, 2 were tae type I, 1 was type II, i was type III and the remaining 5 were the mixed type of I and II.

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Recently, six cases of anencephalus were experienced.
The adrenal cortex of anencephalus was hypoplastic and the weight was about tenth of the normal baby. Luck of the anterior pituitary was observed Study of anencephalus is, important to clarify the mechanism of biosynthesis of estrogens. Urine of two cases of anencephalus pregnant women were analyzed for estrogens and plasma of other two cases were analyzed for estriol. Urinary estrogen level of anencephalus was lower than that of normal pregnancy. Urinary estriol concentration was 3.9 per cent of normal pregnancy. Plasma estriol concentration of anencephalus was about ten per cent of normal pregnancy but the ratio of the maternal antecubital vein and the umbirical vessels was equal to that of normal pregnancy.

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In the present experiment, diethyl-paranitrophenyl-thiophosphate in a varying dose of 2, 4, 8, 12 and 16 mg/kg was injected subcutaneously into female rats, and after repeating the injections required, they were mated with normal male rats. Pathological investigations were made on the kidney of the new borns thus obtained (sacrificed on the 3rd adn 7th day after birth) and of the maternal rats, and at the same time, the relationship of the effect of maternal intoxication to the placental cord was investigated.
In summarizing the renal findings of acute groups, they can be said as the acute diffusive glomerulonephritis accompanying the alternative “ Veränderung ” of the tubular epithelium. As for the changes produced in the glomeruli, moreover, the toxic effect is considered to exert direct primary damages on the endothelial cells of the loop.
Consolidative changes observed on chronic groups are the final picture of acute glomerulonephritis and interstitial hydroma is considered to have played the most important role in the production of these fibrotic changes.
Renal disorders of the suckling rats were proved to consist of inflammatory, retrogressiv and growth disturbing changes. The fact that the renal changes of the suckling rats were always milder than those of the mother rats is construed as the expression of the inhibitory influence of the placental cord against the transmission of toxic substances.

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